Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 102507

Incomplete block of B cell development and immunoglobulin production in mice carrying the uMT mutation on the BALB/c background


Hasan, Milena; Polić, Bojan; Bralić, Marina; Jonjić, Stipan; Rajewsky, Klaus
Incomplete block of B cell development and immunoglobulin production in mice carrying the uMT mutation on the BALB/c background // European journal of immunology, 32 (2002), 12; 3463-3471 (međunarodna recenzija, članak, znanstveni)


Naslov
Incomplete block of B cell development and immunoglobulin production in mice carrying the uMT mutation on the BALB/c background

Autori
Hasan, Milena ; Polić, Bojan ; Bralić, Marina ; Jonjić, Stipan ; Rajewsky, Klaus

Izvornik
European journal of immunology (0014-2980) 32 (2002), 12; 3463-3471

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
B cell; muMT; B cell development

Sažetak
The expression of the preB cell receptor (preBCR), composed of the mu chain, surrogate light chains and the Igalpha /Igbeta signal transduction unit, permits further differentiation of Bcell precursors. C57BL/6 mice homozygous for an inactivating mutation of the membrane exon of the mu chain gene (C57BL/6muMT/muMT)) cannot form a preBCR and are, consequently, devoid of mature B lymphocytes. Here we present evidence that the block of B cell development by the muMT mutation is incomplete in BALB/c mice. Unlike C57BL/6muMT/muMT), BALB/cmuMT/muMT) mice generate small numbers of mature B cells, accumulate plasma cells and produce high levels of all immunoglobulin isotypes, except IgM. The observed phenomenon seems to be controlled by a single genetic locus that is not linked to IgH.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Veterinarska medicina



POVEZANOST RADA


Projekt / tema
0062004
0062005
0062007

Ustanove
Medicinski fakultet, Rijeka

Profili:

Avatar Url Milena Hasan (autor)

Avatar Url Marina Bralić (autor)

Avatar Url Stipan Jonjić (autor)

Avatar Url Bojan Polić (autor)

Citiraj ovu publikaciju

Hasan, Milena; Polić, Bojan; Bralić, Marina; Jonjić, Stipan; Rajewsky, Klaus
Incomplete block of B cell development and immunoglobulin production in mice carrying the uMT mutation on the BALB/c background // European journal of immunology, 32 (2002), 12; 3463-3471 (međunarodna recenzija, članak, znanstveni)
Hasan, M., Polić, B., Bralić, M., Jonjić, S. & Rajewsky, K. (2002) Incomplete block of B cell development and immunoglobulin production in mice carrying the uMT mutation on the BALB/c background. European journal of immunology, 32 (12), 3463-3471.
@article{article, year = {2002}, pages = {3463-3471}, keywords = {B cell, muMT, B cell development}, journal = {European journal of immunology}, volume = {32}, number = {12}, issn = {0014-2980}, title = {Incomplete block of B cell development and immunoglobulin production in mice carrying the uMT mutation on the BALB/c background}, keyword = {B cell, muMT, B cell development} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • Index Medicus