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Pregled bibliografske jedinice broj: 1022678

Pharmacokinetic Profiling and Simultaneous Determination of Thiopurine Immunosuppressants and Folic Acid by Chromatographic Methods


Brusač, Edvin; Jeličić, Mario-Livio; Amidžić Klarić, Daniela; Nigović, Biljana; Turk, Nikša; Klarić, Ilija; Mornar, Ana
Pharmacokinetic Profiling and Simultaneous Determination of Thiopurine Immunosuppressants and Folic Acid by Chromatographic Methods // Molecules, 24 (2019), 19; 3469, 18 doi:10.3390/molecules24193469 (međunarodna recenzija, članak, znanstveni)


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Naslov
Pharmacokinetic Profiling and Simultaneous Determination of Thiopurine Immunosuppressants and Folic Acid by Chromatographic Methods

Autori
Brusač, Edvin ; Jeličić, Mario-Livio ; Amidžić Klarić, Daniela ; Nigović, Biljana ; Turk, Nikša ; Klarić, Ilija ; Mornar, Ana

Izvornik
Molecules (1420-3049) 24 (2019), 19; 3469, 18

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
inflammatory bowel disease ; fixed-dose combination ; biomimetic chromatography ; thiopurine immunosuppressants ; folic acid

Sažetak
With the increase in the number of medicines patients have to take, there has been a rapid rise of fixed-dose combinations (FDCs) in the last two decades. Prior to FDC development, pharmacokinetic properties of active pharmaceutical ingredients (APIs) have to be evaluated, as well as methods for their determination developed. So as to increase patient compliance in inflammatory bowel disease, three novel FDCs of thiopurine immunosuppressants and folic acid are proposed ; physico-chemical and pharmacokinetic properties such as hydrophobicity, lipophilicity and plasma protein binding of all APIs are evaluated. Moreover, experimental results of different properties are compared to those computed by various on-line prediction platforms so as to evaluate the viability of the in silico approach. A simultaneous method for their determination is developed, optimized, validated and applied to commercial tablet formulations. The method has shown to be fast, selective, accurate and precise, showing potential for reliable determination of API content in proposed FDCs during its development.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Farmacija



POVEZANOST RADA


Projekt / tema
HRZZ-DOK-2017-01-9047 - HRZZ-DOK-2017-01-9047 (, )
HRZZ-UIP-2017-05-3949 - Razvoj naprednih analitičkih metoda za lijekove i biološki aktivne tvari u liječenju upalnih bolesti crijeva (IBDAnalytics) (Mornar Turk, Ana, HRZZ - 2017-05 )

Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb

Citiraj ovu publikaciju

Brusač, Edvin; Jeličić, Mario-Livio; Amidžić Klarić, Daniela; Nigović, Biljana; Turk, Nikša; Klarić, Ilija; Mornar, Ana
Pharmacokinetic Profiling and Simultaneous Determination of Thiopurine Immunosuppressants and Folic Acid by Chromatographic Methods // Molecules, 24 (2019), 19; 3469, 18 doi:10.3390/molecules24193469 (međunarodna recenzija, članak, znanstveni)
Brusač, E., Jeličić, M., Amidžić Klarić, D., Nigović, B., Turk, N., Klarić, I. & Mornar, A. (2019) Pharmacokinetic Profiling and Simultaneous Determination of Thiopurine Immunosuppressants and Folic Acid by Chromatographic Methods. Molecules, 24 (19), 3469, 18 doi:10.3390/molecules24193469.
@article{article, year = {2019}, pages = {18}, DOI = {10.3390/molecules24193469}, chapter = {3469}, keywords = {inflammatory bowel disease, fixed-dose combination, biomimetic chromatography, thiopurine immunosuppressants, folic acid}, journal = {Molecules}, doi = {10.3390/molecules24193469}, volume = {24}, number = {19}, issn = {1420-3049}, title = {Pharmacokinetic Profiling and Simultaneous Determination of Thiopurine Immunosuppressants and Folic Acid by Chromatographic Methods}, keyword = {inflammatory bowel disease, fixed-dose combination, biomimetic chromatography, thiopurine immunosuppressants, folic acid}, chapternumber = {3469} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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