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Pregled bibliografske jedinice broj: 1022611

An observational, multicentre study on different insulin glargine U100 titration algorithms used in patients with type 2 diabetes in daily medical practice in Adriatic countries: The ADRESA study


Krnić, Mladen; Marolt, Iris; Skelin, Marko; Grulović, Natasa; Rahelić, Dario
An observational, multicentre study on different insulin glargine U100 titration algorithms used in patients with type 2 diabetes in daily medical practice in Adriatic countries: The ADRESA study // Diabetes Research and Clinical Practice, 150 (2019), 144-149 doi:10.1016/j.diabres.2019.01.001 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1022611 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
An observational, multicentre study on different insulin glargine U100 titration algorithms used in patients with type 2 diabetes in daily medical practice in Adriatic countries: The ADRESA study

Autori
Krnić, Mladen ; Marolt, Iris ; Skelin, Marko ; Grulović, Natasa ; Rahelić, Dario

Izvornik
Diabetes Research and Clinical Practice (0168-8227) 150 (2019); 144-149

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Glycaemic control ; HbA1c ; Insulin glargine ; Titration algorithms ; Type 2 diabetes mellitus

Sažetak
Abstract AIMS: To compare the effectiveness of different titration algorithms for insulin glargine U100 used in everyday practice to achieve glycaemic targets in patients with type 2 diabetes mellitus (T2DM). METHODS: A total of 526 patients (278 in Slovenia, 248 in Croatia) with T2DM (aged ≥ 18 years) and treated with insulin glargine prior to inclusion were enrolled. Patients self-titrated insulin glargine according to physicians' guidance. RESULTS: Among the 524 patients included in the final analysis, the titration algorithm from the LANMET study was used most commonly (n = 368, 70.5% patients), followed by the Treat-To- Target (TTT) algorithm (n = 117, 22.4%). At the end of the study (6 months), 179 (34.3%) patients reached HbA1c ≤ 7%. There was no significant difference in the proportion of patients who reached their target HbA1c between the different algorithms at 6 months (35.6% using LANMET, 30.7% with TTT, and 32.4% with other algorithms ; p = 0.611). HbA1c levels were more significantly reduced in patients using the TTT algorithm compared to LANMET (-2.31%, vs. -1.57% ; p < 0.05). The proportion of patients with reported symptomatic hypoglycaemia did not differ significantly between the algorithms. CONCLUSIONS: Continuous titration of insulin glargine U100 is a safe and efficient option for T2DM management, regardless of the titration algorithm applied.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove:
Opća bolnica Šibenik

Profili:

Avatar Url Dario Rahelić (autor)

Avatar Url Marko Skelin (autor)

Citiraj ovu publikaciju

Krnić, Mladen; Marolt, Iris; Skelin, Marko; Grulović, Natasa; Rahelić, Dario
An observational, multicentre study on different insulin glargine U100 titration algorithms used in patients with type 2 diabetes in daily medical practice in Adriatic countries: The ADRESA study // Diabetes Research and Clinical Practice, 150 (2019), 144-149 doi:10.1016/j.diabres.2019.01.001 (međunarodna recenzija, članak, znanstveni)
Krnić, M., Marolt, I., Skelin, M., Grulović, N. & Rahelić, D. (2019) An observational, multicentre study on different insulin glargine U100 titration algorithms used in patients with type 2 diabetes in daily medical practice in Adriatic countries: The ADRESA study. Diabetes Research and Clinical Practice, 150, 144-149 doi:10.1016/j.diabres.2019.01.001.
@article{article, year = {2019}, pages = {144-149}, DOI = {10.1016/j.diabres.2019.01.001}, keywords = {Glycaemic control, HbA1c, Insulin glargine, Titration algorithms, Type 2 diabetes mellitus}, journal = {Diabetes Research and Clinical Practice}, doi = {10.1016/j.diabres.2019.01.001}, volume = {150}, issn = {0168-8227}, title = {An observational, multicentre study on different insulin glargine U100 titration algorithms used in patients with type 2 diabetes in daily medical practice in Adriatic countries: The ADRESA study}, keyword = {Glycaemic control, HbA1c, Insulin glargine, Titration algorithms, Type 2 diabetes mellitus} }
@article{article, year = {2019}, pages = {144-149}, DOI = {10.1016/j.diabres.2019.01.001}, keywords = {Glycaemic control, HbA1c, Insulin glargine, Titration algorithms, Type 2 diabetes mellitus}, journal = {Diabetes Research and Clinical Practice}, doi = {10.1016/j.diabres.2019.01.001}, volume = {150}, issn = {0168-8227}, title = {An observational, multicentre study on different insulin glargine U100 titration algorithms used in patients with type 2 diabetes in daily medical practice in Adriatic countries: The ADRESA study}, keyword = {Glycaemic control, HbA1c, Insulin glargine, Titration algorithms, Type 2 diabetes mellitus} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
  • Scopus
  • MEDLINE


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