Enhanced protection of biological membranes during lipid peroxidation using flavonoid loaded mesoporous silica nanoparticles (CROSBI ID 681182)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Sadžak, Anja ; Mandić, Lucija ; Strasser, Vida ; Baranović, Goran ; Domazet Jurašin, Darija ; Dutour Sikirić, Maja ; Šegota, Suzana
engleski
Enhanced protection of biological membranes during lipid peroxidation using flavonoid loaded mesoporous silica nanoparticles
Flavonoids, polyphenols with anti-oxidative activity have high potential as novel therapeutics for neurodegenerative disease, but their applicability is rendered by their poor water solubility and chemical instability under physiological conditions. In this study, this is overcome by delivering flavonoids to model cell membranes (unsaturated DOPC) using prepared and characterized biodegradable mesoporous silica nanoparticles, MSNs. Quercetin, myricetin and myricitrin have been investigated in order to determine the relationship between flavonoid structure and protective activity towards oxidative stress i.e. lipid peroxidation induced by addition of hydrogen peroxide and/or Cu2+ ions. Among investigated flavonoids, quercetin showed the most enhanced and prolonged protective anti- oxidative activity. The nanomechanical (Young modulus) measurement of the MSNs treated DOPC membranes during lipid peroxidation confirmed attenuated membrane damage. By applying combination of experimental techniques (AFM, force spectroscopy, ELS, DLS), this work generated detailed knowledge about the effects of flavonoid loaded MSNs on the elasticity of model membranes, especially under oxidative stress conditions. Results from this study will pave the way towards the development of innovative and improved markers for oxidative stress-associated neurological disorders. In addition, the obtained could be extended to designing effective delivery systems of other high potential bioactive molecules with an aim to improve human health in general.
Lipid peroxidation ; flavonoids ; silica nanoparticles
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Podaci o prilogu
43-43.
2019.
objavljeno
Podaci o matičnoj publikaciji
33rd Conference of The European Colloid and Interface Society : Book of abstracts
Koos, Erin ; Demeyere, Hugo
Leuven: The European Colloid and Interface Society
Podaci o skupu
33rd Conference of The European Colloid and Interface Society
poster
08.09.2019-13.09.2019
Leuven, Belgija