engleski

Elevated Neutrophil–to–Lymphocyte-ratio and Platelet–to–Lymphocyte Ratio in Myelofibrosis: Inflammatory Biomarkers or Representatives of Myeloproliferation Itself?

Background/Aim: We aimed to investigate clinical associations of inflammatory biomarkers neutrophil- tolymphocyte- ratio (NLR) and platelet-to- lymphocyte-ratio (PLR) in patients with myelofibrosis, myeloproliferative neoplasm with inflammatory background. Patients and Methods: We retrospectively analyzed a cohort of 102 myelofibrosis patients. NLR and PLR were assessed in addition to other diseasespecific parameters. Results: NLR and PLR were significantly higher in myelofibrosis than in healthy controls. Higher NLR was significantly associated with Janus-kinase- 2 (JAK2)- mutation, wild-type-Calreticulin (CALR), older age and parameters reflecting increased proliferative potential of disease (higher leukocytes, higher hemoglobin, larger spleensize), whereas there was no significant association with C-reactive-protein (CRP). Higher PLR was significantly associated with absence of blast-phase-disease, absence of constitutional-symptoms, lower percentage-of- circulatoryblasts, smaller spleen-size and lower CRP. In the Coxregression- model, higher- NLR (HR=2.76 ; p=0.004), lower- PLR (HR=1.99 ; p=0.042) and Dynamic- International- Prognostic- System (DIPSS) (HR=3.26 ; p<0.001) predicted inferior survival independently of each other. Conclusion: In the context of myelofibrosis, elevated NLR and PLR are more likely to represent myeloproliferation itself and not necessary the extent of inflammation.

philadelphia chromosome negative myeloproliferative neoplasm ; primary myelofibrosis ; secondary myelofibrosis ; inflammatory biomarkers ; survival

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