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Pregled bibliografske jedinice broj: 1021984

Synthesis and antimicrobial potential of quaternary 3-aminoquinuclidinium salts with long alkyl chains


Bazina, Linda; Maravić, Ana; Odžak, Renata; Primožič, Ines; Šprung, Matilda
Synthesis and antimicrobial potential of quaternary 3-aminoquinuclidinium salts with long alkyl chains // /
Beč, Austrija, 2019. (poster, međunarodna recenzija, neobjavljeni rad, znanstveni)


Naslov
Synthesis and antimicrobial potential of quaternary 3-aminoquinuclidinium salts with long alkyl chains

Autori
Bazina, Linda ; Maravić, Ana ; Odžak, Renata ; Primožič, Ines ; Šprung, Matilda

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, neobjavljeni rad, znanstveni

Skup
EUROPIN Summer School on Drug Design – Vienna

Mjesto i datum
Beč, Austrija, 15-20.09.2019

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Quaternary ammonium compounds (QAC) ; Antimicrobial activity ; Cytotoxicity

Sažetak
Emerging antibiotic resistance is one of the biggest threats to public health and there is a crucial need for development of new effective antibiotics. Quaternary ammonium compounds (QACs), as cationic amphiphiles, have been recognized as broad-spectrum antibacterial agents. In this paper, we have designed and synthesized cationic surfactant systems based on quinuclidine bearing an amino group and a long side alkyl chain (C12 and C14) assuming that amino group would upgrade ability of bacterial membrane disruption (Figure 1). These compounds are characterized by FT-IR, 1H NMR and 13C NMR analysis and are evaluated for antimicrobial activity against representative Gram-positive and -negative bacterial strains. The minimal inhibitory and bactericidal concentrations (MIC and MBC) are determined by using the method of a serial dilution. Our results show a positive correlation between antimicrobial activity and an alkyl chain length. Tested compounds exhibit noteworthy antibacterial activity, especially, QNH2-C14 with considerably low minimal inhibitory concentration against S. aureus (MIC = 3.9 μg mL-1), S. pyogenes (MIC = 3.9 μg mL-1) and E. faecalis (MIC = 1.95 μg mL-1). The work on cytotoxicity measurements toward different human cell lines is currently in progress.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija



POVEZANOST RADA


Projekt / tema
HRZZ-IP-2016-06-3775 - Aktivnošću i in silico usmjeren dizajn malih bioaktivnih molekula (Tomica Hrenar, )

Ustanove
Prirodoslovno-matematički fakultet, Zagreb,
Prirodoslovno-matematički fakultet, Split