engleski

Microscoping the amoeboid cell motility

Transition from mesenchymal to amoeboid cell migration is a hallmark of tumor metastasis. Genuine amoeboid motility is most appropriately studied in amoeba such as Dictyostelium. The core motility mechanisms conserved from amoebozoa to mammals are based on fast remodeling of the actin cytoskeleton regulated by small GTPases. I will present a retrospective of a quarter century of cell motility research in Dictyostelium and give an overview of the contemporary evolution of digital microscopy techniques with the focus on live cell imaging [1-15].

cell motility ; small GTPases ; amoeboid cell migration ; Dictyostelium ; light microscopy

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