engleski

Design, synthesis and immunostimulating activity of mannosylated desmuramyl peptides

Muramyl dipeptide (MDP), N-acetylmuramyl-L-alanyl- D-isoglutamine, is the smallest structural unit of bacterial peptidoglycan responsible for eliciting of immune response. It acts as a pathogen- associated molecular pattern and activates nucleotide-binding oligomerization domain- containing protein 2 (NOD2). [1] Desmuramyl peptides possess L-Ala-D-isoGln pharmacophore which is essential for the immunostimulatory properties. We have designed mannosylated desmuramly peptides (Figure 1) using multiple pathogen recognition receptor activation approach. [2] Mannose receptors are C-type lectin receptors expressed on immunocompetent cells and represent additional pattern recognition target for affecting immune system. [3]Adamantane was introduced in order to increase the lipophilicity of L-Ala-D-isoGln peptide and to facilitate the anchoring of the compound to the lipid bilayer.

adamantane, desmuramyl peptides, mannose, immunostimulating activity

nije evidentirano