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DESIGN, SYNTHESIS AND IMMUNOSTIMULATING ACTIVITY OF MANNOSYLATED DESMURAMYL PEPTIDES


Ribić, Rosana; Tomić, Srđanka
DESIGN, SYNTHESIS AND IMMUNOSTIMULATING ACTIVITY OF MANNOSYLATED DESMURAMYL PEPTIDES // Peptide Chemistry Day
Zagreb, Hrvatska, 2019. str. 11-11 (predavanje, domaća recenzija, sažetak, znanstveni)


Naslov
DESIGN, SYNTHESIS AND IMMUNOSTIMULATING ACTIVITY OF MANNOSYLATED DESMURAMYL PEPTIDES

Autori
Ribić, Rosana ; Tomić, Srđanka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
Peptide Chemistry Day

Mjesto i datum
Zagreb, Hrvatska, 19.09.2019

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
Adamantane, desmuramyl peptides, mannose, immunostimulating activity

Sažetak
Muramyl dipeptide (MDP), N-acetylmuramyl-L-alanyl- D-isoglutamine, is the smallest structural unit of bacterial peptidoglycan responsible for eliciting of immune response. It acts as a pathogen-associated molecular pattern and activates nucleotide-binding oligomerization domain-containing protein 2 (NOD2). [1] Desmuramyl peptides possess L-Ala-D-isoGln pharmacophore which is essential for the immunostimulatory properties. We have designed mannosylated desmuramly peptides (Figure 1) using multiple pathogen recognition receptor activation approach. [2] Mannose receptors are C-type lectin receptors expressed on immunocompetent cells and represent additional pattern recognition target for affecting immune system. [3]Adamantane was introduced in order to increase the lipophilicity of L-Ala-D-isoGln peptide and to facilitate the anchoring of the compound to the lipid bilayer.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti



POVEZANOST RADA


Ustanove
Prirodoslovno-matematički fakultet, Zagreb,
Sveučilište Sjever, Koprivnica