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Pregled bibliografske jedinice broj: 1021306

Antiproliferative evaluation of various aminoquinoline derivatives


Zorc, Branka; Rajić, Zrinka; Perković, Ivana
Antiproliferative evaluation of various aminoquinoline derivatives // Acta pharmaceutica, 69 (2019), 661-672 (međunarodna recenzija, članak, znanstveni)


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Naslov
Antiproliferative evaluation of various aminoquinoline derivatives

Autori
Zorc, Branka ; Rajić, Zrinka ; Perković, Ivana

Izvornik
Acta pharmaceutica (1330-0075) 69 (2019); 661-672

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
primaquine, chloroquine, mefloquine, fumardiamide, antiproliferative activity

Sažetak
Four classes of aminoquinoline derivatives were prepared: primaquine ureas 1a–f, primaquine bis-ureas 2a–f, chloroquine fumardiamides 3a–f and mefloquine fumardiamides 4a–f. Their antiproliferative activities against breast adenocarcinoma (MCF-7), lung carcinoma (H460) and colon carcinoma (HCT 116 and SW620) cell lines were evaluated in vitro, using MTT cell proliferation assay. The results revealed a low activity of primaquine urea and bis-urea derivatives and high activity of all fumardiamides, with IC50 values in low micromolar range against all tested cancer cell lines.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija



POVEZANOST RADA


Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb

Profili:

Avatar Url Zrinka Rajić (autor)

Avatar Url Ivana Perković (autor)

Avatar Url Branka Zorc (autor)

Citiraj ovu publikaciju

Zorc, Branka; Rajić, Zrinka; Perković, Ivana
Antiproliferative evaluation of various aminoquinoline derivatives // Acta pharmaceutica, 69 (2019), 661-672 (međunarodna recenzija, članak, znanstveni)
Zorc, B., Rajić, Z. & Perković, I. (2019) Antiproliferative evaluation of various aminoquinoline derivatives. Acta pharmaceutica, 69, 661-672.
@article{article, year = {2019}, pages = {661-672}, keywords = {primaquine, chloroquine, mefloquine, fumardiamide, antiproliferative activity}, journal = {Acta pharmaceutica}, volume = {69}, issn = {1330-0075}, title = {Antiproliferative evaluation of various aminoquinoline derivatives}, keyword = {primaquine, chloroquine, mefloquine, fumardiamide, antiproliferative activity} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





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