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Pregled bibliografske jedinice broj: 1021029

Antimycobacterial activity of harminices, harmine derived triazoles


Rodrigues-Junior, Valnes; Abbadi, Bruno; Basso, Luiz A; Perković, Ivana; Rajić, Zrinka
Antimycobacterial activity of harminices, harmine derived triazoles // Book of abstracts, EFMC/ASMC VII EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry / Aggrawal, Varinder ; Liras, Spiros (ur.).
Atena: EFMC, 2019. str. 311-311 (poster, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 1021029 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Antimycobacterial activity of harminices, harmine derived triazoles

Autori
Rodrigues-Junior, Valnes ; Abbadi, Bruno ; Basso, Luiz A ; Perković, Ivana ; Rajić, Zrinka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of abstracts, EFMC/ASMC VII EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry / Aggrawal, Varinder ; Liras, Spiros - Atena : EFMC, 2019, 311-311

Skup
International Symposium on Advances in Synthetic and Medicinal Chemistry

Mjesto i datum
Atena, Grčka, 1-5.09.2019

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
harmine, cinnamic acid, 1, 2, 3-triazole, synthesis

Sažetak
Tuberculosis (TB) remains one of the major golbal health problems with 10 million new cases (1 million children) in 2017. In 2017 TB was one of the top 10 causes of death worldwide killing 1.3 million people, ranking above HIV/AIDS as the leading cause of death from an infectious disease (1). New treatment options are urgent in order to resolve some of the major issues in current anti-TB therapy ; the emergence of multidrug-resistant (MDR-TB) and extensively drug resistant (XDR-TB) strains which require prolonged and complex treatment and toxicity. The efforts in antimycobacterial drug discovery in the last decade resulted in two new oral drugs for the treatment of TB, delamanid and bedaquiline (2). β-Carbolines such as hamine and harmole are alkaloids found in Peganim harmala and Eurycoma longifolia plants. They have been evaluated extensively for various pharmacological activities, including antimycobacterial (3). Their various synthetic analogues have been prepared and tested for antimycobacterial activity as well (4, 5). We have prepared 26 derivatives of triazole bridged harmine/harmole and cinnamyl moiety. Here we report the results of the antimycobacterial screening. Minimum inhibitory concentrations (MIC) were determined in Mycobacterium tuberculosis H37Rv, a virulent strain, by using the resazurin reduction microplate assay. Further evaluations are necessary to investigate the toxicological properties and the potential of 8g or 8h as new anti-tuberculosis drug candidate.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Farmacija



POVEZANOST RADA


Projekt / tema
HRZZ-UIP-2017-05-5160 - Derivati harmina kao potencijalni antimalarici (Zrinka Rajić Džolić, HRZZ)

Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb

Profili:

Avatar Url Zrinka Rajić (autor)

Avatar Url Ivana Perković (autor)

Citiraj ovu publikaciju

Rodrigues-Junior, Valnes; Abbadi, Bruno; Basso, Luiz A; Perković, Ivana; Rajić, Zrinka
Antimycobacterial activity of harminices, harmine derived triazoles // Book of abstracts, EFMC/ASMC VII EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry / Aggrawal, Varinder ; Liras, Spiros (ur.).
Atena: EFMC, 2019. str. 311-311 (poster, međunarodna recenzija, sažetak, znanstveni)
Rodrigues-Junior, V., Abbadi, B., Basso, L., Perković, I. & Rajić, Z. (2019) Antimycobacterial activity of harminices, harmine derived triazoles. U: Aggrawal, V. & Liras, S. (ur.)Book of abstracts, EFMC/ASMC VII EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry.
@article{article, year = {2019}, pages = {311-311}, keywords = {harmine, cinnamic acid, 1, 2, 3-triazole, synthesis}, title = {Antimycobacterial activity of harminices, harmine derived triazoles}, keyword = {harmine, cinnamic acid, 1, 2, 3-triazole, synthesis}, publisher = {EFMC}, publisherplace = {Atena, Gr\v{c}ka} }




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