Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 1020819

RAPID GOLGI IMPREGNATION OF PYRAMIDAL NEURONS IN THE PREFRONTAL CORTEX IN SCHIZOPHRENIA


Banovac, Ivan; Sedmak, Dora; Rojnić Kuzman, Martina; Hladnik, Ana; Petanjek, Zdravko
RAPID GOLGI IMPREGNATION OF PYRAMIDAL NEURONS IN THE PREFRONTAL CORTEX IN SCHIZOPHRENIA // 7th Croatian Neuroscience Congress - Book of Abstracts
Zadar, Hrvatska, 2019. str. 34-34 (poster, domaća recenzija, sažetak, znanstveni)


CROSBI ID: 1020819 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
RAPID GOLGI IMPREGNATION OF PYRAMIDAL NEURONS IN THE PREFRONTAL CORTEX IN SCHIZOPHRENIA

Autori
Banovac, Ivan ; Sedmak, Dora ; Rojnić Kuzman, Martina ; Hladnik, Ana ; Petanjek, Zdravko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
7th Croatian Neuroscience Congress - Book of Abstracts / - , 2019, 34-34

Skup
7th Croatian Neuroscience Congress

Mjesto i datum
Zadar, Hrvatska, 12.-15.09.2019

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
rapid Golgi staining, prefrontal cortex, pyramidal neurons, schizophrenia, axon impregnation

Sažetak
Abnormalities in oligodendrocytes lead to altered myelination in schizophrenia, according to most recent studies. The degree of myelination affects axon impregnation in Golgi staining. Therefore, the aim of this study is to compare the axon impregnation on rapid Golgi between schizophrenic and control subjects. We analyzed sections of the prefrontal cortex containing Brodmann area 9 in five schizophrenic and five control subjects. The sections were stained using the rapid Golgi method and the axons of randomly selected pyramidal neurons of layer III and V were reconstructed using Neurolucida 4 software. The axon impregnation lengths were then compared between the schizophrenic and control groups. Our results showed an increase in the length of axonal staining of the pyramidal neurons in the prefrontal cortices of schizophrenic subjects. The length of the stained axon main trunk was 132.5 ± 63.5 µm in the schizophrenic group and 64.8 ± 20.2 µm in the control group. The difference was shown to be statistically significant (p-value on Student’s t-test was <0.05). Our analysis also revealed that more axon collaterals per neuron were stained in the schizophrenic group (14.5% on average) than in the control group (5.1% on average). The increased axonal staining in schizophrenic subjects could be explained by reduced myelination of the axons, which allows for better impregnation on Golgi staining. Such a decrease in axon myelination is in line with the neurodevelopmental model of schizophrenia, which proposes that pathology in schizophrenia is more dependent on secondary effects, rather than on a primary lesion. In conclusion, our results support that the cortical circuitry disorganization in schizophrenia is caused by oligodendrocyte abnormalities which lead to a decrease in axon myelination.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
HRZZ-IP-2013-11-5943 - Neuralna osnova viših spoznajnih funkcija (Zdravko Petanjek, )
HRZZ-UIP-2014-09-1245 - Biomarkeri u shizofreniji – integracija komplementarnih prisutupa u praćenju osoba s prvom psihotičnom epizodom (Martina Rojnic Kuzman, )

Ustanove
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb

Citiraj ovu publikaciju

Banovac, Ivan; Sedmak, Dora; Rojnić Kuzman, Martina; Hladnik, Ana; Petanjek, Zdravko
RAPID GOLGI IMPREGNATION OF PYRAMIDAL NEURONS IN THE PREFRONTAL CORTEX IN SCHIZOPHRENIA // 7th Croatian Neuroscience Congress - Book of Abstracts
Zadar, Hrvatska, 2019. str. 34-34 (poster, domaća recenzija, sažetak, znanstveni)
Banovac, I., Sedmak, D., Rojnić Kuzman, M., Hladnik, A. & Petanjek, Z. (2019) RAPID GOLGI IMPREGNATION OF PYRAMIDAL NEURONS IN THE PREFRONTAL CORTEX IN SCHIZOPHRENIA. U: 7th Croatian Neuroscience Congress - Book of Abstracts.
@article{article, year = {2019}, pages = {34-34}, keywords = {rapid Golgi staining, prefrontal cortex, pyramidal neurons, schizophrenia, axon impregnation}, title = {RAPID GOLGI IMPREGNATION OF PYRAMIDAL NEURONS IN THE PREFRONTAL CORTEX IN SCHIZOPHRENIA}, keyword = {rapid Golgi staining, prefrontal cortex, pyramidal neurons, schizophrenia, axon impregnation}, publisherplace = {Zadar, Hrvatska} }