engleski

Biocatalysis for the production of pharmaceutical intermediates: statin precursors

The application of enzymes in the chemical synthesis, due to the recent advances, has a strong impact in multiple industries, especially the pharmaceutical industry. Namely, the use of enzymes shows remarkable advantages over the classical chemical catalysis and therefore it is considered as a ‘green’ solution. Using novel techniques, it is possible to completely tailor the enzymes in order to adapt them for the given process. As of today, several pharmaceutical companies are successfully producing valuable precursors for the production of active pharmaceutical ingredients using enzymes, some of them being statin precursors. Statins are hypolipidemics, drugs used for the prevention of cardiovascular diseases and for lowering cholesterol concentration in blood. Due to challenges in the chemical synthesis of statin intermediates, the production of statin intermediates using enzyme-catalyzed reactions shows some notable advantages. Therefore, the research and development laboratories, combined with reaction engineering techniques, have shifted their focus towards applying the biochemical catalysis for the production of statin intermediates.

enzymes ; biocatalysis ; green chemistry ; precursors ; pharmaceutical industry ; statins

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