engleski

Multimodal evoked potentials and their correlation with cerebral vasomotor reactivity in advanced PD patients

Introduction: Advanced Parkinson’s disease patients with motor fluctuations that can no longer be controlled with medications are candidates for deep brain stimulation (DBS). Conflicting data about multimodal evoked potential changes, and cerebral vasomotor reactivity in those patients before and after DBS were described in literature. Aims: To determine the changes in latencies and amplitudes of visual, brainstem auditory, and somatosensory evoked potentials in advanced PD patients in comparison with healthy controls, and to correlate them with the changes in cerebral vasomotor reactivity, as well as to brainstem nuclei alterations. Methods: Measurements of latencies and amplitudes of visual, brainstem auditory and somatosensory evoked potentials (especially frontal N30 marker) were done in 10 advanced PD patients (HY 2-4), and compared to the results of the same measurements in 10 healthy controls matched for age and sex. Subsequently, transcranial Doppler was used to measure cerebral vasomotor reactivity, as well as for the detection of brainstem nuclei changes. The results were correlated to patient motor UPDRS scores. Results and conclusion: The preliminary results of this study demonstrated that significant differences in evoked potentials between PD patients and normal controls were observed. Furthermore, we were able to constantly correlate changes in evoked potentials with cerebral vasomotor reactivity as well as with changes in brainstem nuclei. Based on our findings, we hypothesize that this could potentially be a good marker for the evaluation of the successfulness of deep brain stimulation in PD patients. This work was supported by Croatian Science Foundation Start-Up grant awarded to G.S.

Evoked potentials ; deep brain stimulation ; Parkinson's disease ; transcranial doppler

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