engleski

Application of adamantyl aminoguanidines infunctional self-assembled nanovesicles

Combination of a lipophilic adamantyl subunit and a highly polar guanidine moiety affords adamantylaminoguanidines, compounds with membrane compatible features capable of binding to complementary molecules possessing phosphate groups.[1] We recently showed that adamantylaminoguanidines can effectively be incorporated into liposomes and the resulting liposomeformulations were capable of recognizing complementary liposomes.[2] We therefore turned outattention to preparing multicomponent self-assembled supramolecular nanovesicles capable of recognition and binding to fluorescently labelled DNA.[3] Our findings suggest that such nanovesicles(Figure 1) could potentially be applied as nonviral gene delivery vectors.

adamantyl aminoguanidines ; model membrane systems ; nanovesicles ; liposomes

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