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Pregled bibliografske jedinice broj: 1019281

Spatially clustered loci with multiple enhancers are frequent targets of HIV-1 integration


Lucic, Bojana; Chen, Heng-Chang; Kuzman, Maja; Zorita, Eduard; Wegner, Julia; Minneker, Vera; Wang, Wei; Fronza, Raffaele; Laufs, Stefanie; Schmidt, Manfred et al.
Spatially clustered loci with multiple enhancers are frequent targets of HIV-1 integration // Nature Communications, 10 (2019), 1; 4059, 12 doi:10.1038/s41467-019-12046-3 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1019281 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Spatially clustered loci with multiple enhancers are frequent targets of HIV-1 integration

Autori
Lucic, Bojana ; Chen, Heng-Chang ; Kuzman, Maja ; Zorita, Eduard ; Wegner, Julia ; Minneker, Vera ; Wang, Wei ; Fronza, Raffaele ; Laufs, Stefanie ; Schmidt, Manfred ; Stadhouders, Ralph ; Roukos, Vassilis ; Vlahovicek, Kristian ; Filion, Guillaume J. ; Lusic, Marina

Izvornik
Nature Communications (2041-1723) 10 (2019), 1; 4059, 12

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
HIV-1 integration ; multiple enhancers ; spatial compartmentalization

Sažetak
HIV-1 recurrently targets active genes and integrates in the proximity of the nuclear pore compartment in CD4+ T cells. However, the genomic features of these genes and the relevance of their transcriptional activity for HIV-1 integration have so far remained unclear. Here we show that recurrently targeted genes are proximal to super-enhancer genomic elements and that they cluster in specific spatial compartments of the T cell nucleus. We further show that these gene clusters acquire their location during the activation of T cells. The clustering of these genes along with their transcriptional activity are the major determinants of HIV-1 integration in T cells. Our results provide evidence of the relevance of the spatial compartmentalization of the genome for HIV-1 integration, thus further strengthening the role of nuclear architecture in viral infection.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA


Projekti:
KK.01.1.1.01.0010
HRZZ-IP-2014-09-6400 - Istraživanje razvoja, diferencijacije i evolucije životinja kroz genomiku bazalnih metazoa (BAMGEN) (Vlahoviček, Kristian, HRZZ - 2014-09) ( POIROT)
KK.01.1.1.01.0009 - Napredne metode i tehnologije u znanosti o podatcima i kooperativnim sustavima (EK )

Ustanove:
Prirodoslovno-matematički fakultet, Zagreb

Profili:

Avatar Url Kristian Vlahoviček (autor)

Avatar Url Maja Kuzman (autor)

Citiraj ovu publikaciju

Lucic, Bojana; Chen, Heng-Chang; Kuzman, Maja; Zorita, Eduard; Wegner, Julia; Minneker, Vera; Wang, Wei; Fronza, Raffaele; Laufs, Stefanie; Schmidt, Manfred et al.
Spatially clustered loci with multiple enhancers are frequent targets of HIV-1 integration // Nature Communications, 10 (2019), 1; 4059, 12 doi:10.1038/s41467-019-12046-3 (međunarodna recenzija, članak, znanstveni)
Lucic, B., Chen, H., Kuzman, M., Zorita, E., Wegner, J., Minneker, V., Wang, W., Fronza, R., Laufs, S. & Schmidt, M. (2019) Spatially clustered loci with multiple enhancers are frequent targets of HIV-1 integration. Nature Communications, 10 (1), 4059, 12 doi:10.1038/s41467-019-12046-3.
@article{article, year = {2019}, pages = {12}, DOI = {10.1038/s41467-019-12046-3}, chapter = {4059}, keywords = {HIV-1 integration, multiple enhancers, spatial compartmentalization}, journal = {Nature Communications}, doi = {10.1038/s41467-019-12046-3}, volume = {10}, number = {1}, issn = {2041-1723}, title = {Spatially clustered loci with multiple enhancers are frequent targets of HIV-1 integration}, keyword = {HIV-1 integration, multiple enhancers, spatial compartmentalization}, chapternumber = {4059} }
@article{article, year = {2019}, pages = {12}, DOI = {10.1038/s41467-019-12046-3}, chapter = {4059}, keywords = {HIV-1 integration, multiple enhancers, spatial compartmentalization}, journal = {Nature Communications}, doi = {10.1038/s41467-019-12046-3}, volume = {10}, number = {1}, issn = {2041-1723}, title = {Spatially clustered loci with multiple enhancers are frequent targets of HIV-1 integration}, keyword = {HIV-1 integration, multiple enhancers, spatial compartmentalization}, chapternumber = {4059} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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