engleski

Neuroendocrine structures in prostate cancer patients.

In prostate cancer pts serum CgA denotes the progression in NE differentiation and not only necessary of small cell carcinoma. NE cells communicate with adenocarcinoma in a paracrine way to promote hormone refractory prostate cancer that resists hormonal manipulation. Therefore, CgA elevation in serum and tissue requires a rapid change in treatment strategy swithing to chemo(hormonal)therapy and the application of bisphosphonates. Latest data indicate a link between osteolysis and NE differentiation.

prostate cancer; NE structures; risk for progression and metastases; CgA values

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