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Changes in saliva of dogs with canine leishmaniosis: A proteomic approach


Franco-Martínez, Lorena; Tvarijonaviciute, Asta; Horvatić, Anita; Guillemin, Nicolas; Bernal, Luis Jesús; Barić Rafaj, Renata; Cerón, José Joaquín; Thomas, María del Carmen; López, Manuel C.; Tecles, Fernando et al.
Changes in saliva of dogs with canine leishmaniosis: A proteomic approach // Veterinary Parasitology, 272 (2019), 44-52 doi:10.1016/j.vetpar.2019.06.014 (međunarodna recenzija, članak, znanstveni)


Naslov
Changes in saliva of dogs with canine leishmaniosis: A proteomic approach

Autori
Franco-Martínez, Lorena ; Tvarijonaviciute, Asta ; Horvatić, Anita ; Guillemin, Nicolas ; Bernal, Luis Jesús ; Barić Rafaj, Renata ; Cerón, José Joaquín ; Thomas, María del Carmen ; López, Manuel C. ; Tecles, Fernando ; Martínez-Subiela, Silvia ; Mrljak, Vladimir

Izvornik
Veterinary Parasitology (0304-4017) 272 (2019); 44-52

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Biomarkers Saliva Leishmaniosis Dog Gel-free proteomics Tandem mass tag

Sažetak
In the present study, a quantitative proteomic approach to study changes in saliva proteins associated with canine leishmaniosis (CanL) was performed. For this, canine salivary proteins were analysed and compared between dogs before (T0) and after (T1) experimental infection with Leishmania infantum by high-throughput label-based quantitative LC–MS/MS proteomic approach and bioinformatic analysis of the in silico inferred interactome protein network was created from the initial list of differential proteins. More than 2000 proteins were identified, and of the 90 differentially expressed proteins between T0 and T1, 12 were down-regulated with log2 fold change lower than −0.5849, and 19 were up- regulated with log2 fold change greater than 0.5849. This study provides evidence of changes in salivary proteome that can occur in canine leishmaniosis and revealed biological pathways in saliva modulated in canine leishmaniosis with potential for further targeted research.

Izvorni jezik
Engleski

Znanstvena područja
Veterinarska medicina



POVEZANOST RADA


Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
  • Scopus
  • MEDLINE


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