Mononuclear cobalt, nickel and copper complexes with glycinamide: structural properties and biological activity (CROSBI ID 680317)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Prugovečki, Biserka ; Vušak, Darko ; Smrečki, Neven ; Kralj, Marijeta ; Uzelac, Lidija ; Matković-Čalogović, Dubravka
engleski
Mononuclear cobalt, nickel and copper complexes with glycinamide: structural properties and biological activity
Glycinamide (HL) is the simplest amino acid amide, cheap and available and easily synthesized. In the CSD there are only six structures containing the glycinamide fragment: glycinamide hydrochloride, two rhodium complexes, a bimetallic (Mn, Cr) ferrimagnet, a ruthenium complex and an iridium complex. As a part of our ongoing research on investigation of metal complexes with amino acids and their derivatives, we report synthesis, solid-state characterization and antiproliferative activity of cobalt, nickel and copper complexes with glycinamide. In the cobalt(II) and nickel(II) complexes [M(H2O)2(HL)2]X2 (M = Co, Ni ; X = Cl, Br/Cl, I), the metal(II) cation is octahedrally coordinated by two glycinamide molecules in a cis-fashion and by two water molecules. In [CuCl2(HL)2] and [CuBr1.3Cl0.7(HL)2] the octahedral coordination environment around the Cu(II) ions consists of two N, O-bidentate glycinamide ligands in a trans-fashion and two halide ions. [Co(H2O)2(HL)2]Cl2 and [CuCl2(HL)2] showed moderate antiproliferative activity and selectivity towards MCF-7 cell lines. The research was supported by the Croatian Science Foundation, project “Essential metal ions in Helicobacter pylori proteins and model complexes structure and function/property” (HRZZ-IP-2014-09-4274).
glycinamide ; cobalt ; nickel ; copper
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Podaci o prilogu
546-546.
2019.
objavljeno
Podaci o matičnoj publikaciji
32nd European Crystallographic Meeting : book of abstracts
Beč: European Crystallographic Meeting
Podaci o skupu
32nd European Crystallographic Meeting
poster
18.08.2019-23.08.2019
Beč, Austrija