engleski

Visceral obesity measured by dual X‐ray absorptiometry and bioimpedance as the predictor for IBS in obese patients

Objective: The evidence regarding the relationship between visceral abdominal tissue (VAT) and the incidence of irritable bowel syndrome (IBS) are sparse. Moreover, the exact measurement method for VAT is still debatable. Lee. GC et.al reported VAT measurement by CT scan which is an invasive and expensive method and not appropriate in everyday usage. We aimed to measure VAT by dual‐energy x‐ray absorptiometry (DEXA) and biometric impedance and correlate the values with the presence of IBS symptoms. The primary outcome of this study was to investigate the association between VAT and the risk of IBS. The secondary outcome is to compare two different methods for VAT measurement. Methods: Totally we enrolled 94 obese patients (76.5% F ; mean age M = 47.99 ; SD = 11.8 years). In this case‐control study we compare the VAT, Fatty mass (FM), Free Fatty Mass (FFM), Waist circumference (WC) between subjects with obesity and IBS (IBS group N = 29 ; 30.9%) and controls (obese patients without IBS, non‐IBS group N = 65 ; 69.1%), who underwent obesity programme at tertiary care centre from January 2018. to January 2019. IBS was diagnosed by using Rome IV criteria questionnaire. The association between IBS and abdominal obesity was evaluated by measuring VAT, FFM, FM and waist circumference (WC) using DEXA and bioimpedance. Results: The prevalence of IBS in this sample was 30.8%, (OR 0.44 ; 95% (CI): 0.2645 to 0.7525, P = 0.0025) among all enrolled subjects. VAT(L) measured by bioimpedance is significant predictor for IBS in obese patients t = 2.51, df = 63.51, p < .05 (p = 0.01468) ; Cohen's d = 0.51 (moderately high) IBS (M = 4.27 ; SD = 2.35), non‐IBS (M = 6.09 ; SD = 3.94). Moreover, there is a significant correlation between VAT measurement with bioimpedance and DEXA. FFM, FM and WC as well are not important predictors for IBS in obese patients. Younger obese patients are more prone to have IBS symptoms than older patients (OR 0.93 ; 95%(CI): 0.88 to 0.97 ; P = 0.007). Conclusions: Visceral adiposity measured by the simple and non‐invasive method is associated with an increased risk of IBS. Bioimpedance and DEXA are reliable methods for VAT measurement. However, neither FFM, FM, BMI and WC are associated with an increased risk of IBS.

Bioimpedance ; Dual X‐ray absorptiometry ; Irritable bowel syndrome ; Obesity

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