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Pregled bibliografske jedinice broj: 1017292

Altered N-glycosylation profiles as potential biomarkers and drug targets in diabetes


Rudman, Najda; Gornik, Olga; Lauc, Gordan
Altered N-glycosylation profiles as potential biomarkers and drug targets in diabetes // FEBS letters, 593 (2019), 13; 1598-1615 doi:10.1002/1873-3468.13495 (međunarodna recenzija, pregledni rad, znanstveni)


CROSBI ID: 1017292 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Altered N-glycosylation profiles as potential biomarkers and drug targets in diabetes

Autori
Rudman, Najda ; Gornik, Olga ; Lauc, Gordan

Izvornik
FEBS letters (0014-5793) 593 (2019), 13; 1598-1615

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
glycosyltransferase ; HNF1A-MODY ; N-glycosylation ; type 1 diabetes ; type 2 diabetes

Sažetak
N-glycosylation is a ubiquitous protein modification, and N-glycosylation profiles are emerging as both biomarkers and functional effectors in various types of diabetes. Genome- wide association studies identified glycosyltransferase genes as candidate causal genes for type 1 and type 2 diabetes. Studies focused on N-glycosylation changes in type 2 diabetes demonstrated that patients can be distinguished from healthy controls based on N- glycome composition. In addition, individuals at an increased risk of future disease development could be identified based on N- glycome profiles. Moreover, accumulating evidence indicates that N-glycans have a major role in preventing the impairment of glucose- stimulated insulin secretion by maintaining the glucose transporter in proper orientation, indicating that interindividual variation in protein N-glycosylation might be a novel risk factor contributing to diabetes development. Defective N-glycosylation of T cells has been implicated in type 1 diabetes pathogenesis. Furthermore, studies of N-glycan alterations have successfully been used to identify individuals with rare types of diabetes (such as the HNF1A-MODY), and also to evaluate functional significance of novel diabetes- associated mutations. In conclusion, both N- glycans and glycosyltransferases emerge as potential therapeutic targets in diabetes.

Izvorni jezik
Engleski

Znanstvena područja
Interdisciplinarne prirodne znanosti



POVEZANOST RADA


Projekti:
KK.01.2.1.01.0003
KK.01.1.1.01.0010
721815 - Innovative training in methods for future data (IMforFUTURE) (Zoldoš, Vlatka; Lauc, Gordan, EK - H2020-MSCA-ITN-2016) ( POIROT)
HRZZ-UIP-2014-09-7769 - Glikozilacija plazmatskih proteina u razumijevanju dijabetesa tipa 1 (GLYCO-T1D) (Gornik, Olga, HRZZ - 2014-09) ( POIROT)
722095 - Exploitation of Glycosylation Signatures for Precision Medicine (GlySign) (EK - H2020-MSCA-ITN-2016) ( POIROT)

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
GENOS d.o.o.

Profili:

Avatar Url Olga Gornik Kljaić (autor)

Avatar Url Najda Rudman (autor)

Avatar Url Gordan Lauc (autor)

Citiraj ovu publikaciju

Rudman, Najda; Gornik, Olga; Lauc, Gordan
Altered N-glycosylation profiles as potential biomarkers and drug targets in diabetes // FEBS letters, 593 (2019), 13; 1598-1615 doi:10.1002/1873-3468.13495 (međunarodna recenzija, pregledni rad, znanstveni)
Rudman, N., Gornik, O. & Lauc, G. (2019) Altered N-glycosylation profiles as potential biomarkers and drug targets in diabetes. FEBS letters, 593 (13), 1598-1615 doi:10.1002/1873-3468.13495.
@article{article, year = {2019}, pages = {1598-1615}, DOI = {10.1002/1873-3468.13495}, keywords = {glycosyltransferase, HNF1A-MODY, N-glycosylation, type 1 diabetes, type 2 diabetes}, journal = {FEBS letters}, doi = {10.1002/1873-3468.13495}, volume = {593}, number = {13}, issn = {0014-5793}, title = {Altered N-glycosylation profiles as potential biomarkers and drug targets in diabetes}, keyword = {glycosyltransferase, HNF1A-MODY, N-glycosylation, type 1 diabetes, type 2 diabetes} }
@article{article, year = {2019}, pages = {1598-1615}, DOI = {10.1002/1873-3468.13495}, keywords = {glycosyltransferase, HNF1A-MODY, N-glycosylation, type 1 diabetes, type 2 diabetes}, journal = {FEBS letters}, doi = {10.1002/1873-3468.13495}, volume = {593}, number = {13}, issn = {0014-5793}, title = {Altered N-glycosylation profiles as potential biomarkers and drug targets in diabetes}, keyword = {glycosyltransferase, HNF1A-MODY, N-glycosylation, type 1 diabetes, type 2 diabetes} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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