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Pregled bibliografske jedinice broj: 1016908

Primaquine derivatives: Modifications of the terminal amino group


Zorc, Branka; Perković, Ivana; Pavić, Kristina; Rajić, Zrinka; Beus, Maja
Primaquine derivatives: Modifications of the terminal amino group // European journal of medicinal chemistry, 182 (2019), 111640, 19 doi:10.1016/j.ejmech.2019.111640 (međunarodna recenzija, pregledni rad, znanstveni)


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Naslov
Primaquine derivatives: Modifications of the terminal amino group

Autori
Zorc, Branka ; Perković, Ivana ; Pavić, Kristina ; Rajić, Zrinka ; Beus, Maja

Izvornik
European journal of medicinal chemistry (0223-5234) 182 (2019); 111640, 19

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
Primaquine derivatives ; Antiplasmodial activity ; Antiproliferative activity ; Antibacterial activity ; Antibiofilm ; Antioxidative activity

Sažetak
Numerous modifications of the well-known antimalarial drug primaquine, both at the quinoline ring and at the primary amino group, have been reported, mostly to obtain antimalarial agents with improved bioavailability, reduced toxicity and/or prolonged activity. Modifications of the terminal amino group were made with the main idea to prevent the metabolic pathway leading to inactive and toxic carboxyprimaquine (follow-on strategy), but also to get compounds with different activity (repurposing strategy). The modifications undertaken until 2009 were included in a review published in the same year. The present review covers various classes of primaquine N-derivatives with diverse biological profiles, prepared in the last decade by our research group as well as the others. We have summarized the synthetic procedures applied for their preparation and discussed the main biological results. Several hits for the development of novel antiplasmodial, anticancer, antimycobacterial and antibiofilm agents were identified.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Interdisciplinarne prirodne znanosti, Farmacija



POVEZANOST RADA


Projekt / tema
HRZZ-IP-09-2014-1501

Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb

Profili:

Avatar Url Zrinka Rajić (autor)

Avatar Url Ivana Perković (autor)

Avatar Url Branka Zorc (autor)

Avatar Url Kristina Pavić (autor)

Avatar Url Maja Beus (autor)

Citiraj ovu publikaciju

Zorc, Branka; Perković, Ivana; Pavić, Kristina; Rajić, Zrinka; Beus, Maja
Primaquine derivatives: Modifications of the terminal amino group // European journal of medicinal chemistry, 182 (2019), 111640, 19 doi:10.1016/j.ejmech.2019.111640 (međunarodna recenzija, pregledni rad, znanstveni)
Zorc, B., Perković, I., Pavić, K., Rajić, Z. & Beus, M. (2019) Primaquine derivatives: Modifications of the terminal amino group. European journal of medicinal chemistry, 182, 111640, 19 doi:10.1016/j.ejmech.2019.111640.
@article{article, year = {2019}, pages = {19}, DOI = {10.1016/j.ejmech.2019.111640}, chapter = {111640}, keywords = {Primaquine derivatives, Antiplasmodial activity, Antiproliferative activity, Antibacterial activity, Antibiofilm, Antioxidative activity}, journal = {European journal of medicinal chemistry}, doi = {10.1016/j.ejmech.2019.111640}, volume = {182}, issn = {0223-5234}, title = {Primaquine derivatives: Modifications of the terminal amino group}, keyword = {Primaquine derivatives, Antiplasmodial activity, Antiproliferative activity, Antibacterial activity, Antibiofilm, Antioxidative activity}, chapternumber = {111640} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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