Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 1016819

Fine-Mapping of the Human Blood Plasma N-Glycome onto Its Proteome


Suhre, Karsten; Trbojević-Akmačić, Irena; Ugrina, Ivo; Mook-Kanamori, Dennis; Spector, Tim; Graumann, Johannes; Lauc, Gordan; Falchi, Mario
Fine-Mapping of the Human Blood Plasma N-Glycome onto Its Proteome // Metabolites, 9 (2019), 7; 122, 4 doi:10.3390/metabo9070122 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1016819 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Fine-Mapping of the Human Blood Plasma N-Glycome onto Its Proteome

Autori
Suhre, Karsten ; Trbojević-Akmačić, Irena ; Ugrina, Ivo ; Mook-Kanamori, Dennis ; Spector, Tim ; Graumann, Johannes ; Lauc, Gordan ; Falchi, Mario

Izvornik
Metabolites (2218-1989) 9 (2019), 7; 122, 4

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
glycomics ; proteomics ; N-glycosylation ; population study ; aptamers ; HILIC-UPLC ; SOMAscan

Sažetak
Most human proteins are glycosylated. Attachment of complex oligosaccharides to the polypeptide part of these proteins is an integral part of their structure and function and plays a central role in many complex disorders. One approach towards deciphering this human glycan code is to study natural variation in experimentally well characterized samples and cohorts. High-throughput capable large-scale methods that allow for the comprehensive determination of blood circulating proteins and their glycans have been recently developed, but so far, no study has investigated the link between both traits. Here we map for the first time the blood plasma proteome to its matching N-glycome by correlating the levels of 1116 blood circulating proteins with 113 N-glycan traits, determined in 344 samples from individuals of Arab, South-Asian, and Filipino descent, and then replicate our findings in 46 subjects of European ancestry. We report protein-specific N- glycosylation patterns, including a correlation of core fucosylated structures with immunoglobulin G (IgG) levels, and of trisialylated, trigalactosylated, and triantennary structures with heparin cofactor 2 (SERPIND2). Our study reveals a detailed picture of protein N-glycosylation and suggests new avenues for the investigation of its role and function in the associated complex disorders.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija



POVEZANOST RADA


Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb,
Prirodoslovno-matematički fakultet, Split,
GENOS d.o.o.

Profili:

Avatar Url Gordan Lauc (autor)

Avatar Url Ivo Ugrina (autor)

Avatar Url Irena Trbojević Akmačić (autor)

Citiraj ovu publikaciju

Suhre, Karsten; Trbojević-Akmačić, Irena; Ugrina, Ivo; Mook-Kanamori, Dennis; Spector, Tim; Graumann, Johannes; Lauc, Gordan; Falchi, Mario
Fine-Mapping of the Human Blood Plasma N-Glycome onto Its Proteome // Metabolites, 9 (2019), 7; 122, 4 doi:10.3390/metabo9070122 (međunarodna recenzija, članak, znanstveni)
Suhre, K., Trbojević-Akmačić, I., Ugrina, I., Mook-Kanamori, D., Spector, T., Graumann, J., Lauc, G. & Falchi, M. (2019) Fine-Mapping of the Human Blood Plasma N-Glycome onto Its Proteome. Metabolites, 9 (7), 122, 4 doi:10.3390/metabo9070122.
@article{article, year = {2019}, pages = {4}, DOI = {10.3390/metabo9070122}, chapter = {122}, keywords = {glycomics, proteomics, N-glycosylation, population study, aptamers, HILIC-UPLC, SOMAscan}, journal = {Metabolites}, doi = {10.3390/metabo9070122}, volume = {9}, number = {7}, issn = {2218-1989}, title = {Fine-Mapping of the Human Blood Plasma N-Glycome onto Its Proteome}, keyword = {glycomics, proteomics, N-glycosylation, population study, aptamers, HILIC-UPLC, SOMAscan}, chapternumber = {122} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Emerging Sources Citation Index (ESCI)
  • Scopus


Citati