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Simultaneous Occurrence of Primary Skin Melanoma and its Metastasis to the Ampulla of Vater: A Case Report

Malignant melanoma has the capability to disseminate widely to almost any organ in the body. The gastrointestinal tract is frequently involved by this tumor. Reports on metastatic melanoma of ampullary region and biliary system are rare. A 46-year-old male patient presented with obstructive jaundice. Pathohistologic analysis of endoscopic biopsy of the ampulla of Vater suggested metastatic melanoma. Two weeks before, the patient had undergone surgery due to an ulcerated tumor of the index finger of the right hand. Pathohistologic analysis showed acral melanoma (Clark V, Breslow V). Subsequently, Whipple resection of the pancreas, duodenum, and distal bile duct revealed a metastatic melanoma in the ampulla of Vater extending to the duodenal wall. The patient had brain metastasis at 9 and then again at 17 months after the diagnosis, and died 20 months after initial presentation. Autopsy was not performed.

Melanoma, complications ; Melanoma, secondary ; Vater’s ampulla ; Common bile duct neoplasms, complications ; Case report

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