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Pregled bibliografske jedinice broj: 1016454

Maximum Entropy Production Theorem for Transitions between Enzyme Functional States and Its Applications


Juretić, Davor; Simunić, Juraj; Bonačić Lošić, Željana
Maximum Entropy Production Theorem for Transitions between Enzyme Functional States and Its Applications // Entropy (Basel. Online), 21 (2019), 8; 743, 20 doi:10.3390/e21080743 (međunarodna recenzija, članak, znanstveni)


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Naslov
Maximum Entropy Production Theorem for Transitions between Enzyme Functional States and Its Applications

Autori
Juretić, Davor ; Simunić, Juraj ; Bonačić Lošić, Željana

Izvornik
Entropy (Basel. Online) (1099-4300) 21 (2019), 8; 743, 20

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
entropy production ; triosephosphate isomerase ; ATP synthase ; β-lactamases ; bacteriorhodopsin

Sažetak
Transitions between enzyme functional states are often connected to conformational changes involving electron or proton transport and directional movements of a group of atoms. These microscopic fluxes, resulting in entropy production, are driven by non-equilibrium concentrations of substrates and products. Maximal entropy production exists for any chosen transition, but such a maximal transitional entropy production (MTEP) requirement does not ensure an increase of total entropy production, nor an increase in catalytic performance. We examine when total entropy production increases, together with an increase in the performance of an enzyme or bioenergetic system. The applications of the MTEP theorem for transitions between functional states are described for the triosephosphate isomerase, ATP synthase, for β-lactamases, and for the photochemical cycle of bacteriorhodopsin. The rate-limiting steps can be easily identified as those which are the most efficient in dissipating free-energy gradients and in performing catalysis. The last step in the catalytic cycle is usually associated with the highest free-energy dissipation involving proton nanocurents. This recovery rate-limiting step can be optimized for higher efficiency by using corresponding MTEP requirements. We conclude that biological evolution, leading to increased optimal catalytic efficiency, also accelerated the thermodynamic evolution, the synergistic relationship we named the evolution-coupling hypothesis.

Izvorni jezik
Engleski

Znanstvena područja
Fizika, Biologija



POVEZANOST RADA


Ustanove
Institut "Ruđer Bošković", Zagreb,
Prirodoslovno-matematički fakultet, Split,
Mediteranski institut za istraživanje života

Citiraj ovu publikaciju

Juretić, Davor; Simunić, Juraj; Bonačić Lošić, Željana
Maximum Entropy Production Theorem for Transitions between Enzyme Functional States and Its Applications // Entropy (Basel. Online), 21 (2019), 8; 743, 20 doi:10.3390/e21080743 (međunarodna recenzija, članak, znanstveni)
Juretić, D., Simunić, J. & Bonačić Lošić, Ž. (2019) Maximum Entropy Production Theorem for Transitions between Enzyme Functional States and Its Applications. Entropy (Basel. Online), 21 (8), 743, 20 doi:10.3390/e21080743.
@article{article, year = {2019}, pages = {20}, DOI = {10.3390/e21080743}, chapter = {743}, keywords = {entropy production, triosephosphate isomerase, ATP synthase, β-lactamases, bacteriorhodopsin}, journal = {Entropy (Basel. Online)}, doi = {10.3390/e21080743}, volume = {21}, number = {8}, issn = {1099-4300}, title = {Maximum Entropy Production Theorem for Transitions between Enzyme Functional States and Its Applications}, keyword = {entropy production, triosephosphate isomerase, ATP synthase, β-lactamases, bacteriorhodopsin}, chapternumber = {743} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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