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Pregled bibliografske jedinice broj: 101544

Inbreeding and Nephrolithiasis in Croatian Island Isolates


Rudan, Igor; Padovan, Milko; Rudan, Diana; Campbell, Harry; Biloglav, Zrinka; Janićijević, Branka; Smolej Narančić, Nina; Rudan, Pavao
Inbreeding and Nephrolithiasis in Croatian Island Isolates // Collegium antropologicum, 26 (2002), 1; 11-21 (međunarodna recenzija, članak, znanstveni)


Naslov
Inbreeding and Nephrolithiasis in Croatian Island Isolates

Autori
Rudan, Igor ; Padovan, Milko ; Rudan, Diana ; Campbell, Harry ; Biloglav, Zrinka ; Janićijević, Branka ; Smolej Narančić, Nina ; Rudan, Pavao

Izvornik
Collegium antropologicum (0350-6134) 26 (2002), 1; 11-21

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Inbreeding; nephrolithiasis; isolate populations; genetic factors; Croatia

Sažetak
The aim of this study was to investigate a recessive genetic component in susceptibility to nephrolithiasis (NL) by comparing its prevalence in highly inbred, moderately inbred and non-inbred villages of three Croatian islands: Brac, Hvar and Korcula. The average inbreeding coefficient of each village population (F) was estimated in a random sample of 20-30% adults from 14 villages using Wright's path method (based on genealogical information), isonymy data and average deviation from Hardy-Weinberg expectations for MN, Ss and Kk serogenetic polymorphisms. The six villages with the greatest genealogical F value (0.025-0.049 ; current total population N=1, 401), the four with intermediate value (0.012-0.015 ; N=998) and the four with the smallest value (0.002- 0.008 ; N=1, 500) were chosen for this study. Medical records of entire populations were reviewed and the diagnosis of NL was established according to unified criteria, based on the information from the specialists in general hospitals and on the agreement in diagnosis between the investigators and local general practitioners. The variance in environmental and socio-cultural factors between villages was shown to be minimal. Prevalence of NL in each village was standardised by sex and age to the total population of all 14 villages. The standardized prevalence of NL was 1.5% in the group of villages with low F 2.3% in the group with moderate F (p<0.10), and 5.4% in the group with high F (p<0.001). The correlation factor between F values by villages and the standardized prevalence of NL was 0.45 (p<0.05). The study showed that a large number of predominantly recessive genetic factors might mediate the susceptibility to formation of renal stones in humans.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita



POVEZANOST RADA


Projekt / tema
0108330
01960101

Ustanove
Medicinski fakultet, Zagreb,
Institut za antropologiju

Citiraj ovu publikaciju

Rudan, Igor; Padovan, Milko; Rudan, Diana; Campbell, Harry; Biloglav, Zrinka; Janićijević, Branka; Smolej Narančić, Nina; Rudan, Pavao
Inbreeding and Nephrolithiasis in Croatian Island Isolates // Collegium antropologicum, 26 (2002), 1; 11-21 (međunarodna recenzija, članak, znanstveni)
Rudan, I., Padovan, M., Rudan, D., Campbell, H., Biloglav, Z., Janićijević, B., Smolej Narančić, N. & Rudan, P. (2002) Inbreeding and Nephrolithiasis in Croatian Island Isolates. Collegium antropologicum, 26 (1), 11-21.
@article{article, year = {2002}, pages = {11-21}, keywords = {inbreeding, nephrolithiasis, isolate populations, genetic factors, Croatia}, journal = {Collegium antropologicum}, volume = {26}, number = {1}, issn = {0350-6134}, title = {Inbreeding and Nephrolithiasis in Croatian Island Isolates}, keyword = {inbreeding, nephrolithiasis, isolate populations, genetic factors, Croatia} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Social Science Citation Index (SSCI)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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