engleski

Synthesis, crystal structures, potential energy surfaces and evaluation of antiproliferative effect of 2-benzothiazolylhydrazones

Both benzothiazolyl and hydrazone functional group show diverse biological applications, including: antitumor, antimicrobial, antidiabetic, anticonvulsant and anti- inflammatory activity. Combining them in a unique molecular system could enhance their biological activities, bring new properties and create ligands that have vast and diverse coordination potential to metal centre. The in situ condensation reaction of 2- hydrazinobenzothiazole with salicylaldehyde, 3, 4-dihydroxybenzaldehyde, 2, 4- dihydroxybenzaldehyde, 2, 5- dihydroxybenzaldehyde, 2, 3- dihydroxybenzaldehyde, 2-hydroxy-1- naphthaldehyde, 2-methoxy-1-naphthaldehyde, 4- methoxy-1-naphthaldehyde and 6-methoxy-2- naphthaldehyde produced 9 hydrazone Schiff bases (L1–L9, respectively) which were identified and characterized by elemental analysis, IR and NMR spectroscopy. Strong antiproliferative effects on tumor cells and cytotoxic effects on fibroblasts are shown for all ligands L1–L9 with exception of L6 and L7 that had no effect on fibroblast cells.

Schiff base ligands, Hydrazones, Benzothiazoles, Antiproliferative activity

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