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Pregled bibliografske jedinice broj: 1014942

Synthesis and antiproliferative activity in vitro of amidino substituted 2-phenylbenzazoles


Racané, Livio; Butković, Kristina; Martin- Kleiner, Irena; Kralj, Marijeta; Karminski- Zamola, Grace; Hranjec, Marijana
Synthesis and antiproliferative activity in vitro of amidino substituted 2-phenylbenzazoles // Croatica chemica acta, 92 (2019), 2; 181-189 doi:10.5562/cca3531 (međunarodna recenzija, članak, znanstveni)


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Naslov
Synthesis and antiproliferative activity in vitro of amidino substituted 2-phenylbenzazoles

Autori
Racané, Livio ; Butković, Kristina ; Martin- Kleiner, Irena ; Kralj, Marijeta ; Karminski- Zamola, Grace ; Hranjec, Marijana

Izvornik
Croatica chemica acta (0011-1643) 92 (2019), 2; 181-189

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
amidines ; benzimidazoles ; benzothiazoles ; antiproliferative activity in vitro

Sažetak
Within this work we describe the synthesis of versatile substituted 2-phenyl benzothiazole 3- 10 and 2-phenylbenzimidazole 12-19 derivatives bearing amidino groups. Furthermore, the synthesized compounds were explored for their antiproliferative activity in vitro on three cancer cell lines. Tested compounds showed moderate to strong antiproliferative activity. Furthermore, the type of the attached amidino group on benzazole nuclei has the significant impact on the antiproliferative activity only within benzimidazole derivatives with 2- imidazolinyl substituted derivatives being more active in comparison to amidino substituted analogues. All obtained results revealed that this type of benzothiazole derivatives have a great potential for further optimization and development of more efficient potential antiproliferative agents.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
HRZZ-IP-2018-01-4379 - Istraživanje antioksidativnog djelovanja benzazolskog skeleta u dizajnu novih antitumorskih agensa (AntioxPot) (Hranjec, Marijana, HRZZ - 2018-01) ( POIROT)

Ustanove:
Institut "Ruđer Bošković", Zagreb,
Tekstilno-tehnološki fakultet, Zagreb,
Fakultet kemijskog inženjerstva i tehnologije, Zagreb

Citiraj ovu publikaciju

Racané, Livio; Butković, Kristina; Martin- Kleiner, Irena; Kralj, Marijeta; Karminski- Zamola, Grace; Hranjec, Marijana
Synthesis and antiproliferative activity in vitro of amidino substituted 2-phenylbenzazoles // Croatica chemica acta, 92 (2019), 2; 181-189 doi:10.5562/cca3531 (međunarodna recenzija, članak, znanstveni)
Racané, L., Butković, K., Martin- Kleiner, I., Kralj, M., Karminski- Zamola, G. & Hranjec, M. (2019) Synthesis and antiproliferative activity in vitro of amidino substituted 2-phenylbenzazoles. Croatica chemica acta, 92 (2), 181-189 doi:10.5562/cca3531.
@article{article, year = {2019}, pages = {181-189}, DOI = {10.5562/cca3531}, keywords = {amidines, benzimidazoles, benzothiazoles, antiproliferative activity in vitro}, journal = {Croatica chemica acta}, doi = {10.5562/cca3531}, volume = {92}, number = {2}, issn = {0011-1643}, title = {Synthesis and antiproliferative activity in vitro of amidino substituted 2-phenylbenzazoles}, keyword = {amidines, benzimidazoles, benzothiazoles, antiproliferative activity in vitro} }
@article{article, year = {2019}, pages = {181-189}, DOI = {10.5562/cca3531}, keywords = {amidines, benzimidazoles, benzothiazoles, antiproliferative activity in vitro}, journal = {Croatica chemica acta}, doi = {10.5562/cca3531}, volume = {92}, number = {2}, issn = {0011-1643}, title = {Synthesis and antiproliferative activity in vitro of amidino substituted 2-phenylbenzazoles}, keyword = {amidines, benzimidazoles, benzothiazoles, antiproliferative activity in vitro} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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