engleski

Correspondence analysis applied to large scale Evo-Devo data

Correspondence analysis (CA) is an exploratory method used for visualizing and understanding high dimensional data. It is mostly applied to contingency tables. Although the method has been used in various fields for decades, including bioinformatics, to our knowledge it has not yet been applied tothe evolutionary analysis ofgene expressiondata duringdevelopmental process. In this paperwe present the application of the CA method to linking evolutionaryage of genes and their developmental expression profiles. As a test dataset, we used evolutionary age of genes obtained by phylostratigraphicapproach and expression datacollected during development of a model microorganism. The obtained resultsshow that CA could complement current approaches for coupling evolutionary and developmental information at the molecular level.

correspondence analysis ; evo-devo ; phylostratigraphy ; dimensionality reduction

nije evidentirano