Design, synthesis and characterisation of Cinchona alkaloid carbamates (CROSBI ID 679086)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | domaća recenzija
Podaci o odgovornosti
Ramić, Alma ; Matošević, Ana ; Bosak, Anita ; Kovarik, Zrinka ; Hrenar, Tomica ; Primožič, Ines
engleski
Design, synthesis and characterisation of Cinchona alkaloid carbamates
Cinchona alkaloids and their derivatives are useful in organic chemistry as organocatalysts in stereoselective syntheses, but due to their various bioactive properties they are also very important in medicinal chemistry. To investigate a new class of potentially bioactive Cinchona alkaloids, a series of mono‐ and disubstituted aliphatic (methyl, ethyl and cyclohexyl groups) and mono‐ and disubstituted aromatic (phenyl groups) cinchonine carbamates and their corresponding pseudo‐ enantiomeric cinchonidine carbamates have been prepared and characterized. Structural properties of prepared compounds were studied by FT‐IR, 1D and 2D 1H and 13C NMR spectroscopy. Since some derivatives of cinchonidine have been previously identified as inhibitors of cholinesterases, [1, 2] all prepared carbamate derivatives were screened for their ability to inhibit human acetylcholinesterase and butyrylcholinesterase activity. To explain the differences of the determined carbamylation rates of pseudo‐ enantiomeric carbamates, quantum chemical calculation were used to determine transition states of the carbamylation reaction. Full conformational analysis was performed for all compounds and multi‐way methods were used to correlate inhibition activities with theoretical results. Synthesis, physicochemical characterisation and classification model build by principal component analysis for all compounds will be discussed.
Chinchona alkaloid, carbamates, acetylcholinesterase, butyrylcholinesterase
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Podaci o prilogu
61-61.
2019.
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objavljeno
978-953-6894-67-3
Podaci o matičnoj publikaciji
26. hrvatski skup kemičara i kemijskih inženjera : Knjiga sažetaka
Galić, Nives ; Rogošić, Marko
Zagreb: Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI)
Podaci o skupu
26. hrvatski skup kemičara i kemijskih inženjera (26HSKIKI) ; 4. simpozij Vladimir Prelog
poster
09.04.2019-12.04.2019
Šibenik, Hrvatska