Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 1012869

Serum levels of the high-mobility group box 1 protein (HMGB1) in children with type 1 diabetes mellitus: case-control study


Marjanac, Igor; Lovrić, Robert; Barbić, Jerko
Serum levels of the high-mobility group box 1 protein (HMGB1) in children with type 1 diabetes mellitus: case-control study // Central European Journal of Immunology, 44 (2019), 1; 33-37 doi:10.5114/ceji.2019.84012 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1012869 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Serum levels of the high-mobility group box 1 protein (HMGB1) in children with type 1 diabetes mellitus: case-control study

Autori
Marjanac, Igor ; Lovrić, Robert ; Barbić, Jerko

Izvornik
Central European Journal of Immunology (1426-3912) 44 (2019), 1; 33-37

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
alarmins ; children ; high-mobility group box 1 protein ; inflammation ; type 1 diabetes

Sažetak
INTRODUCTION:The involvement of the high- mobility group box 1 protein (HMGB1) in various autoimmune and inflammatory diseases has been documented ; however, the role of this proinflammatory molecule in children with diabetes type 1 (T1DM) has not been addressed. The aim of this case-control study is to compare the serum level of HMGB1 in children with newly diagnosed T1DM (group 1) and a control group composed of healthy children. MATERIAL AND METHODS: This case-control study included 136 children: group 1 (n = 96) and a control group (n = 40). Measurements were taken from serum for the following: HMGB1, white blood cell count, C- reactive protein, glucose, haemoglobin A1C, and β-cell autoantibodies (GADA-65, IA-2, ICA). HMGB1 was determined using enzyme-linked immunosorbent assay on a Labsystems iEMS Reader MF analyser (Labsystems Diagnostics Oy, Helsinki, Finland). RESULTS: The level (median and interquartile range) of HMGB1 was statistically higher (p < 0.001) in children with T1DM: 8.7 (5.0-9.8) µg/l, in comparison with the control group: 1.0 (0.6-1.4) µg/l. No correlation was found between HMGB1 and HbA1c in group 1, or between HMGB1 and BMI. A statistically higher percentage of positive children for autoantibodies were present in group 1 compared to the control group (p ≤ 0.001). HMGB1 serum levels were also tested and the presence of autoantibodies, and none of those antibodies correlated with the level of HMGB1. CONCLUSIONS: The higher level of HMGB1 in children with T1DM, compared to the control group, indicates that this proinflammatory molecule is a good candidate marker of inflammation in children with T1DM.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove
Klinički bolnički centar Osijek,
Medicinski fakultet, Osijek,
Fakultet za dentalnu medicinu i zdravstvo, Osijek

Profili:

Avatar Url Jerko Barbić (autor)

Avatar Url Robert Lovrić (autor)

Avatar Url Igor Marjanac (autor)

Citiraj ovu publikaciju

Marjanac, Igor; Lovrić, Robert; Barbić, Jerko
Serum levels of the high-mobility group box 1 protein (HMGB1) in children with type 1 diabetes mellitus: case-control study // Central European Journal of Immunology, 44 (2019), 1; 33-37 doi:10.5114/ceji.2019.84012 (međunarodna recenzija, članak, znanstveni)
Marjanac, I., Lovrić, R. & Barbić, J. (2019) Serum levels of the high-mobility group box 1 protein (HMGB1) in children with type 1 diabetes mellitus: case-control study. Central European Journal of Immunology, 44 (1), 33-37 doi:10.5114/ceji.2019.84012.
@article{article, year = {2019}, pages = {33-37}, DOI = {10.5114/ceji.2019.84012}, keywords = {alarmins, children, high-mobility group box 1 protein, inflammation, type 1 diabetes}, journal = {Central European Journal of Immunology}, doi = {10.5114/ceji.2019.84012}, volume = {44}, number = {1}, issn = {1426-3912}, title = {Serum levels of the high-mobility group box 1 protein (HMGB1) in children with type 1 diabetes mellitus: case-control study}, keyword = {alarmins, children, high-mobility group box 1 protein, inflammation, type 1 diabetes} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


Citati