engleski

Distribution of Patients Affected by İbds Based On Family Anamnesis for İbd, Malignancy of Gi Tract and Autoimmune Diseases in Osijek-Baranja County (2000-2014)

BACKGROUND: Inflammatory bowel diseases (IBDs), ulcerative colitis (UC) and Crohn's disease (CD), represent inflammation in the gastrointestinal (GI) tract and often are associated with other autoimmune diseases. Aim of this study was to investigate corelation between IBDs, autoimmune diseases and malignancy of GI tract in family anamnesis. Results in this study are part of the doctoral dissertation of M. Žulj, MD. MATERIAL AND METHODS: This study is based on prevalence of patients with IBDs treated in hospitals in area of Osijek-Baranja County in period of 2000- 2014. Results shown in this study are part of project "Povezanost polimorfizama jednog nukleotida u NOD 2 i MDR 1 genima s nastankom upalnih bolesti crijeva conductedby prof.dr.sc. A.Včev. RESULTS: In researched group of patients negative family anamnesis for IBDs were found in patients with UC (92, 6%) and CD (88, 3%) while positive was found in 9% of patients, notably more in patients with CD (P=0, 008, Fisher's exact test). Similar was found for malignancy of GI tract, negative in 92, 4% patients with UC and 88, 3% patients with CD while positive was found in 9, 1% patients (P=0, 01, Fisher's exact test). There was greater percent of psoriasis (26, 5%), systemic lupus erythematosus (SLE) (14, 3%), Bechterew's disease (15, 3%), rheumatoid arthritis (RA) (12, 2%) and asthma (13, 3%) in family anamnesis of patients with UC unlike patients with CD (0%). Diabetes mellitus (DM) type I was found in family anamnesis of 75% of patients with CD and lower percentage in group of patients with UC, 18, 4% (P<0, 001, Fisher's exact test). CONCLUSION: Although there was negative family anamnesis for IBDs and malignancy of GI tract in patients with IBDs, positive family anamnesis was found for other autoimmune diseases, psoriasis, SLE, Bechterew's disease, RA, asthma in patients with UC and DM type I in patients with CD.

ulcerative colitis ; crohn's disease ; family anamnesis ; autoimmune diseases ; malignancy

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