Mechanisms of Hepatic Cholestatic Drug Injury (CROSBI ID 267487)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Omanović Kolarić, Tea ; Ninčević, Vjera ; Smolić, Robert ; Smolić, Martina ; Wu, George Y
engleski
Mechanisms of Hepatic Cholestatic Drug Injury
Drug-induced cholestasis represents a form of drug-induced liver disease that can lead to severe impairment of liver function. Numerous drugs have been shown to cause cholestasis and consequently bile duct toxicity. However, there is still lack of therapeutic tools that can prevent progression to advanced stages of liver injury. This review focuses on the various pathological mechanisms by which drugs express their hepatotoxic effects, as well as consequences of increased bile acid and toxin accumulation in the hepatocytes.
Drug-induced liver injury, Bile acids, Cholestasis
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Podaci o izdanju
7 (1)
2019.
86-92
objavljeno
2225-0719
2310-8819
10.14218/JCTH.2018.00042