engleski

Circadian Clock Genes and Myocardial Infarction in Patients with type 2 Diabetes Mellitus

Disruption of the circadian clock may trigger the onset of diabetes mellitus and myocardial infarction. Type 2 diabetes mellitus (T2DM) is well-known risk factors for cardiovascular diseases and myocardial infarction. Several physiological factors can stimulate the emergence of T2DM and myocardial infarction, and some of these factors are known to oscillate with circadian rhythms. This study aimed to explore a possible association of the genetic variability in the circadian clock genes ARNTL, CLOCK, and PER2 with myocardial infarction in patients with type 2 diabetes mellitus as an additional risk factor for myocardial infarction. The study group consisted of 231 patients with myocardial infarction and T2DM and a control group of 426 T2DM patients. Altogether, 8 SNPs were tested, three in ARNTL gene (rs3789327, rs4757144 and rs12363415), three in CLOCK (rs11932595, rs6811520 and rs13124436), and two in PER2 (rs35333999 and rs934945). The significance of association for individual SNP was calculated to compare the allelic frequency and genotype distribution in patients and control participants using the Chi-Square test. After using Bonferroni correction significant difference in the distribution of ARNTL rs12363415 polymorphism genotypes were found in patients with myocardial infarction and T2DM in comparison to controls, with a p-value of 1.42x10-4 and odds ratio equal to 7.37 (95% CI: 4.15 to 13.08). Other SNPs in ARNTL, CLOCK, and PER2 genes were not significant additional risk factors for myocardial infarction in T2DM patients. We provide evidence that genetic variation in ARNTL gene might be an additional risk factor for myocardial infarction in T2DM patients.

cardiovascular diseases ; circadian rhythm ; clock genes

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