engleski

Estimation of antibacterial activity of selected macrolides

Antibacterial resistance is currently a major global issue. Antibacterial agents, together with antibiotic-resistant bacteria have been widely detected in different environmental compartments. The activity of antibacterial agents on bacteria may differ based on bacterial species or strain. Due to serious infections caused by multidrug- resistant bacteria, in 2014, the WHO identified antimicrobial resistance as one of the most critical challenges and serious threats to the global public health. Thus, currently, antibacterial agents are regarded as emerging environmental contaminants, with possible implications for human health and ecological status of the environment. The present study aimed to determine the antibacterial activity as well as minimum inhibitory concentrations of azithromycin, erythromycin and tulathromycin against Bacillus subtilis, Pseudomonas aeruginosa and Escherichia coli, respectively. Disc diffusion assay was used to determine antibacterial activity on selected bacteria. Three different concentrations of antibacterial agents were used 40, 80 and 800 mg/L. From obtained results it can be concluded that azithromycin, erythromycin and tulathromycin inhibited the growth of B. subtilis at all examined concentrations. The growth of E. coli was not inhibited by any of examined antibacterial agents and growth of P. aeruginosa was not inhibited by erythromycin, but with azithromycin and tulathromycin was inhibited at all examined concentration.

Antibacterial activity, Bacillus subtilis, Pseudomonas aeruginosa, Escherichia coli, antibiotics

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