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High dietary n6/n3 ratio decreases eicosapentaenoic to arachidonic acid ratios and upregulates NFκB/p50 expression in short-term low-dose streptozotocin and high-fructose rat model of diabetes


Starčević, Kristina; Roškarić, Petra; Šperanda, Marcela; Đidara, Mislav; Gudan Kuriljc, Andrea; Maurić, Maja; Mašek, Tomislav
High dietary n6/n3 ratio decreases eicosapentaenoic to arachidonic acid ratios and upregulates NFκB/p50 expression in short-term low-dose streptozotocin and high-fructose rat model of diabetes // Prostaglandins, Leukotrienes and Essential Fatty Acids, 149 (2019), 1-7 doi:10.1016/j.plefa.2019.07.008 (međunarodna recenzija, članak, znanstveni)


Naslov
High dietary n6/n3 ratio decreases eicosapentaenoic to arachidonic acid ratios and upregulates NFκB/p50 expression in short-term low-dose streptozotocin and high-fructose rat model of diabetes

Autori
Starčević, Kristina ; Roškarić, Petra ; Šperanda, Marcela ; Đidara, Mislav ; Gudan Kuriljc, Andrea ; Maurić, Maja ; Mašek, Tomislav

Izvornik
Prostaglandins, Leukotrienes and Essential Fatty Acids (0952-3278) 149 (2019); 1-7

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Diabetes type 2, Fructose, Streptozotocin, Inflammation, Fatty acids

Sažetak
We studied the influence of dietary n6/n3 ratio and docosahexaenoic (DHA) and eicosapentaenoic (EPA) acids supplementation on fatty acid profile, lipid peroxidation and NFκ/p50 expression in diabetes type 2. Treatments consisted of three dietary n6/n3 ratios: 6 (Control), 50 (high n6) and 1 (DHA and EPA supplemented). Half of the rats in each of the dietary treatments were made diabetic using the fructose/low-streptozotocin model. The Control and high n6 diets decreased EPA/ARA (arachidonic acid) ratios in the plasma and in the hepatic tissue suggesting proinflammatory fatty acid profile. The high n6 diet additionally increased the 4-HNE and NFκ/p50 expression in the hepatic tissue. These changes were the consequence of a decrease in the plasma content of DHA and EPA and an increase in the content of arachidonic acid in the liver neutral lipids. The supplementation with the DHA and EPA attenuated the change in EPA/ARA ratios, which imply the importance of the n6/n3 ratio in diabetes type 2.

Izvorni jezik
Engleski

Znanstvena područja
Veterinarska medicina



POVEZANOST RADA


Projekt / tema
HRZZ-IP-2014-09-8992 - Nutritivna modulacija metabolizma dokozaheksaenske kiseline kod dijabetičke dislipidemije

Ustanove
Veterinarski fakultet, Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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