The aggregation behavior and antioxidative activity of amphiphilic surfactants based on quinuclidin-3-ol (CROSBI ID 267226)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Bošković, Perica ; Šprung, Matilda ; Bazina, Linda ; Soldo, Barbara ; Odžak, Renata
engleski
The aggregation behavior and antioxidative activity of amphiphilic surfactants based on quinuclidin-3-ol
The self-aggregation and thermodynamic properties of three cationic surfactants as quaternary ammonium salts have been investigated. The physicochemical properties of compounds containing quinuclidin-3-ol with even-number of carbon atoms (10, 12 and 14) in the hydrophobic tail were measured by conductivity, dynamic light scattering (DLS) and Zeta-potential measurements. DLS and Zeta- potential measurements show similar size distribution for all surfactants with excellent uniformity, and Zeta-potential increases significantly with increase in the size of hydrocarbon tail. The critical micellar concentration (c.m.c.) and the degree of micelle ionization () were determined using conductivity measurements. The c.m.c. values of surfactants were found to be between 3.4 to 23.8.10-3 M. The standard Gibbs free energy (∆G_mic^o) was derived from conductivity measurements and suggests that surfactants containing longer chains spontaneously form micelles. The antioxidative properties of these cationic surfactants were evaluated using the 2, 2-diphenyl-1-picrylhydrazyl (DPPH) and oxygen radical absorbance capacity (ORAC) assays. Among tested samples, N-tetradecyl-3- hydroxyquinuclidinium bromide (QOH-C14) exhibited the highest antioxidative potential (388.30 nmol (TE) equivalents mL-1), which was further investigated by the DNA nicking assay.
quinuclidinium surfactants ; self-assembly ; micellization thermodynamics ; antioxidants and DNA damage
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Podaci o izdanju
23
2020.
207-214
objavljeno
1097-3958
1558-9293
10.1002/jsde.12348