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Pregled bibliografske jedinice broj: 1011016

Pd(II) complexes with N-heteroaromatic hydrazone ligands: Anticancer activity, in silico and experimental target identification


Bjelogrlić, Snežana K.; Todorović, Tamara R.; Kojić, Milan; Senćanski, Milan; Nikolić, Milan; Višnjevac, Aleksandar; Araškov, Jovana; Miljković, Marija; Mueller, Christian D.; Filipović, Nenad R.
Pd(II) complexes with N-heteroaromatic hydrazone ligands: Anticancer activity, in silico and experimental target identification // Journal of inorganic biochemistry, 199 (2019), 110758, 18 doi:10.1016/j.jinorgbio.2019.110758 (međunarodna recenzija, članak, znanstveni)


Naslov
Pd(II) complexes with N-heteroaromatic hydrazone ligands: Anticancer activity, in silico and experimental target identification

Autori
Bjelogrlić, Snežana K. ; Todorović, Tamara R. ; Kojić, Milan ; Senćanski, Milan ; Nikolić, Milan ; Višnjevac, Aleksandar ; Araškov, Jovana ; Miljković, Marija ; Mueller, Christian D. ; Filipović, Nenad R.

Izvornik
Journal of inorganic biochemistry (0162-0134) 199 (2019); 110758, 18

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Pd(II)complexes ; Hydrazones ; Apoptosis ; Topoisomerase inhibition ; DNAinteractions ; HSAinteractions
(Hydrazones ; Apoptosis ; Topoisomerase inhibition ; DNAinteractions ; HSAinteractions)

Sažetak
Anticancer activity of Pd complexes 1–5 with bidentate N-heteroaromatic hydrazone ligands was investigated on human acute monocytic leukemia (THP-1 ; cells in a suspension) and human mammary adenocarcinoma (MCF-7 ; two-dimensional layer and three-dimensional spheroid tumor model) cell lines. For the Pd(II) complexes with condensation products of ethyl hydrazainoacetate and quinoline-8-carboxaldehyde (complex 1) and 2-formylpyridine (complex 3), for which apoptosis was determined as a mechanism of anticancer activity, further investigation revealed that they arrest the cell cycle in G0/G1 phase, induce generation of reactive oxygen species and inhibit Topoisomerase I in vitro. In silico studies corroborate experimental findings that these complexes show topoisomerase inhibition activity in the micromolar range and indicate binding to a DNA's minor groove as another potential target. Based on the results obtained by circular dichroism and fluorescence spectroscopy measurements, the most active complexes are suitable to be delivered to a blood stream via human serum albumin.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Ustanove
Institut "Ruđer Bošković", Zagreb

Citiraj ovu publikaciju

Bjelogrlić, Snežana K.; Todorović, Tamara R.; Kojić, Milan; Senćanski, Milan; Nikolić, Milan; Višnjevac, Aleksandar; Araškov, Jovana; Miljković, Marija; Mueller, Christian D.; Filipović, Nenad R.
Pd(II) complexes with N-heteroaromatic hydrazone ligands: Anticancer activity, in silico and experimental target identification // Journal of inorganic biochemistry, 199 (2019), 110758, 18 doi:10.1016/j.jinorgbio.2019.110758 (međunarodna recenzija, članak, znanstveni)
Bjelogrlić, S., Todorović, T., Kojić, M., Senćanski, M., Nikolić, M., Višnjevac, A., Araškov, J., Miljković, M., Mueller, C. & Filipović, N. (2019) Pd(II) complexes with N-heteroaromatic hydrazone ligands: Anticancer activity, in silico and experimental target identification. Journal of inorganic biochemistry, 199, 110758, 18 doi:10.1016/j.jinorgbio.2019.110758.
@article{article, year = {2019}, pages = {18}, DOI = {10.1016/j.jinorgbio.2019.110758}, chapter = {110758}, keywords = {Hydrazones, Apoptosis, Topoisomerase inhibition, DNAinteractions, HSAinteractions}, journal = {Journal of inorganic biochemistry}, doi = {10.1016/j.jinorgbio.2019.110758}, volume = {199}, issn = {0162-0134}, title = {Pd(II) complexes with N-heteroaromatic hydrazone ligands: Anticancer activity, in silico and experimental target identification}, keyword = {Hydrazones, Apoptosis, Topoisomerase inhibition, DNAinteractions, HSAinteractions}, chapternumber = {110758} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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