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Pregled bibliografske jedinice broj: 1010709

Quinoline fumardiamides as novel quorum sensing inibitors


Rajić, Zrinka; Petel, JZ; Savijoki, K; Fallarero, A; Yli-Kauhaluoma, J; Beus, Maja; Zorc, Branka
Quinoline fumardiamides as novel quorum sensing inibitors // 11th Joint Meeting on Medicinal Chemistry, Book of Abstracts
Prag, Češka, 2019. str. 117-117 (poster, međunarodna recenzija, sažetak, znanstveni)


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Naslov
Quinoline fumardiamides as novel quorum sensing inibitors

Autori
Rajić, Zrinka ; Petel, JZ ; Savijoki, K ; Fallarero, A ; Yli-Kauhaluoma, J ; Beus, Maja ; Zorc, Branka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
11th Joint Meeting on Medicinal Chemistry, Book of Abstracts / - , 2019, 117-117

Skup
11th Joint Meeting on Medicinal Chemistry

Mjesto i datum
Prag, Češka, 27-30.06.2019

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
quinoline, amides, biofilm, quorum sensing

Sažetak
Conventional antibiotics are inefficient in the treatment of biofilm-associated infections, which complicate treatment of various infections.1 In biofilms, where cells exist as heterogeneous populations with various growth rates (including dormant cells), embedded in a protective matrix, cell-to-cell communication plays an important role.2 This process, termed quorum sensing (QS), seems to be crucial for biofilm formation, and it has emerged as a prominent target for finding effective strategies aimed at biofilm control. In our previous work we have shown that asymmetric primaquine and halogenaniline fumardiamides (1a-f) showed significant activity in biofilm eradication assay.3 As a continuation of our research, we have designed and prepared analogous derivatives with mefloquine (2a-f) and chloroquine (3a-f) pharmacophores and tested anti-QS and bactericidal activity of all quinoline derivatives 1-3.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Farmacija



POVEZANOST RADA


Projekt / tema
6610 - Derivati harmina kao potencijalni antimalarici (Zrinka Rajić Džolić, HRZZ)

Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb

Profili:

Avatar Url Zrinka Rajić (autor)

Avatar Url Branka Zorc (autor)

Avatar Url Maja Beus (autor)

Citiraj ovu publikaciju

Rajić, Zrinka; Petel, JZ; Savijoki, K; Fallarero, A; Yli-Kauhaluoma, J; Beus, Maja; Zorc, Branka
Quinoline fumardiamides as novel quorum sensing inibitors // 11th Joint Meeting on Medicinal Chemistry, Book of Abstracts
Prag, Češka, 2019. str. 117-117 (poster, međunarodna recenzija, sažetak, znanstveni)
Rajić, Z., Petel, J., Savijoki, K., Fallarero, A., Yli-Kauhaluoma, J., Beus, M. & Zorc, B. (2019) Quinoline fumardiamides as novel quorum sensing inibitors. U: 11th Joint Meeting on Medicinal Chemistry, Book of Abstracts.
@article{article, year = {2019}, pages = {117-117}, keywords = {quinoline, amides, biofilm, quorum sensing}, title = {Quinoline fumardiamides as novel quorum sensing inibitors}, keyword = {quinoline, amides, biofilm, quorum sensing}, publisherplace = {Prag, \v{C}e\v{s}ka} }




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