engleski

Challenging Notch Signaling in B-cell Chronic Lymphocytic Leukaemia

B-cell chronic lymphocytic leukaemia (B-CLL) is a lymphoproliferative disorder renowned by the accumulation of malignant cells blocked in the progression of differentiation. The number of patients is expected to grow with population aging, and, considering the heterogeneity of B-CLL, the priority in research should be defining the molecules and signaling pathways underlying its development and progression. B-CLL has been characterized by an increased expression of AIOLOS, an important transcription factor in lymphopoiesis, which has been involved in survival of mature neoplastic B-cells. The aim of our study was to find a relationship between RNA and protein expression of NOTCH1, its downstream target genes HES1 and DELTEX and AIOLOS in B-CLL patients and to determine the leukemic survival when challenged by receptor-ligand interaction in coculture with cells expressing Delta like1 ligand.

Notch signalling ; leukaemia ; B-CLL

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