engleski

Biochemical Characterization of Naturally Occurring HPV-16 E6 and E7 Variants

There are approximately 200 Human papillomaviruses (HPV) which infect humans and a small number of them were shown to be the causative agents of numerous human tumors, with cervical cancer being the most important disease. They are referred to as high risk types and of these HPV-16 and -18 are associated with the majority of HPV-induced malignancies. The two major oncoproteins, E6 and E7, which are encoded by these viruses are directly responsible for the development of the cancers. Among the high risk types, HPV-16 is the most potent viral type in causing cancer. There are however many of HPV-16 variants found in various geographical locations, and they were shown to differ in their abilities to cause cancer. It is clear that some of these variants are more frequently found in cancers than the other variants, implying some likely very important differences in their oncogenic potentials to drive malignant progression. The molecular mechanisms responsible for an increased cancer risk of a number of HPV-16 variants are however still poorly defined.

Human papillomavirus ; E6 oncoprotein ; E6 variants ; cancer ; transformation

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