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Pregled bibliografske jedinice broj: 1009260

Industrial wastewater treatment plant enriches antibiotic resistance genes and alters the structure of microbial communities


Bengtsson-Palme, Johan; Milakovic, Milena; Švecová, Helena; Ganjto, Marin; Jonsson, Viktor; Grabic, Roman; Udikovic-Kolic, Nikolina
Industrial wastewater treatment plant enriches antibiotic resistance genes and alters the structure of microbial communities // Water research, 162 (2019), 437-445 doi:10.1016/j.watres.2019.06.073 (međunarodna recenzija, članak, znanstveni)


Naslov
Industrial wastewater treatment plant enriches antibiotic resistance genes and alters the structure of microbial communities

Autori
Bengtsson-Palme, Johan ; Milakovic, Milena ; Švecová, Helena ; Ganjto, Marin ; Jonsson, Viktor ; Grabic, Roman ; Udikovic-Kolic, Nikolina

Izvornik
Water research (0043-1354) 162 (2019); 437-445

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Antibiotic resistance ; Community structure ; Macrolides ; Pharmaceutical production ; Wastewater treatment

Sažetak
Antibiotic resistance is an emerging global health crisis, driven largely by overuse and misuse of antibiotics. However, there are examples in which the production of these antimicrobial agents has polluted the environment with active antibiotic residues, selecting for antibiotic resistant bacteria and the genes they carry. In this work, we have used shotgun metagenomics to investigate the taxonomic structure and resistance gene composition of sludge communities in a treatment plant in Croatia receiving wastewater from production of the macrolide antibiotic azithromycin. We found that the total abundance of antibiotic resistance genes was three times higher in sludge from the treatment plant receiving wastewater from pharmaceutical production than in municipal sludge from a sewage treatment plant in Zagreb. Surprisingly, macrolide resistance genes did not have higher abundances in the industrial sludge, but genes associated with mobile genetic elements such as integrons had. We conclude that at high concentrations of antibiotics, selection may favor taxonomic shifts towards intrinsically resistant species or strains harboring chromosomal resistance mutations rather than acquisition of mobile resistance determinants. Our results underscore the need for regulatory action also within Europe to avoid release of antibiotics into the environment.

Izvorni jezik
Engleski

Znanstvena područja
Interdisciplinarne prirodne znanosti



POVEZANOST RADA


Projekt / tema
HRZZ-UIP-2014-09-9350 - Istraživanje utjecaja otpadnih voda iz farmaceutskih industrija na sastav i profil antibiotičke rezistencije izloženih mirkobnih zajednica u slatkovodnim sedimentima (Nikolina Udiković Kolić, )

Ustanove
Institut "Ruđer Bošković", Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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