engleski

Modern approach to the treatment of plaque psoriasis

Psoriasis is a common chronic inflammatory skin disease which affects 0.5 to 1% children and 2-3% adult population. In Croatia, 1.6% of population suffer from psoriasis. Distribution of the disease is bi-modal, with the first peak at the age of 20- 30, and the other at the age of 50-60. The etiopathogenesis of the disease is multifactorial, the key factors being genetic predisposition combined with immunological disorders, environmental factors and skin barrier damage. There are several clinical variants of the disease. The main signalling pathways in psoriasis include TNFα, IL-23 and IL-17. Topical agents are used for treatment of the mild form of the disease, and systemic conventional therapy for treatment of moderate to severe forms of the disease. In cases of no response/intolerance or contraindications, new targeted medications are to be administered. Development in the field of immunogenetics of psoriasis leads to the personalized medicine.

psoriasis ; topical treatment ; conventional systemic therapy ; small molecules ; biologicals

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