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Acute toxicity of three novel derivatives of pyridinium chloride to bacteria, human cell culture and rodents


Lovrić, Jasna; Krenajz-Sirotković, Vlasta; Burger, Nicoletta
Acute toxicity of three novel derivatives of pyridinium chloride to bacteria, human cell culture and rodents // Periodicum biologorum, 103 (2001), 4; 347-350 (međunarodna recenzija, članak, znanstveni)


Naslov
Acute toxicity of three novel derivatives of pyridinium chloride to bacteria, human cell culture and rodents

Autori
Lovrić, Jasna ; Krenajz-Sirotković, Vlasta ; Burger, Nicoletta

Izvornik
Periodicum biologorum (0031-5362) 103 (2001), 4; 347-350

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
acute toxicity; LD50; IC50; bioassay; dehidrogenase activity
(acute toxicity; bioassay; Pseudomonas putida; McCoy cells; LD50; IC50)

Sažetak
The search for compounds that contain oxime and keto groups as potential biological and pharmacological active molecules led to the synthesis of three new derivatives of pyridinium chloride. All three monopyridinium compounds BEP, BEPA-4 and FPM-2 were assayed in vitro for their inhibitory effect on human blood cholinesterase and were found to be reverible inhibitors of AChE. Two compounds (FPM-2 and BEPA-4) protected the enzyme from phosphonylation by soman and VX. The pharmacological efficacy of the mentioned compounds was tested on inhibition of cell culture growth (Pseudomonas putida), inhibition of cell culture growth (McCoy) and acute oral mice poisoning (C-57 Black mice).

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
0108051

Ustanove
Medicinski fakultet, Zagreb

Citiraj ovu publikaciju

Lovrić, Jasna; Krenajz-Sirotković, Vlasta; Burger, Nicoletta
Acute toxicity of three novel derivatives of pyridinium chloride to bacteria, human cell culture and rodents // Periodicum biologorum, 103 (2001), 4; 347-350 (međunarodna recenzija, članak, znanstveni)
Lovrić, J., Krenajz-Sirotković, V. & Burger, N. (2001) Acute toxicity of three novel derivatives of pyridinium chloride to bacteria, human cell culture and rodents. Periodicum biologorum, 103 (4), 347-350.
@article{article, year = {2001}, pages = {347-350}, keywords = {acute toxicity, bioassay, Pseudomonas putida, McCoy cells, LD50, IC50}, journal = {Periodicum biologorum}, volume = {103}, number = {4}, issn = {0031-5362}, title = {Acute toxicity of three novel derivatives of pyridinium chloride to bacteria, human cell culture and rodents}, keyword = {acute toxicity, bioassay, Pseudomonas putida, McCoy cells, LD50, IC50} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus