Mechanochemical Friedel–Crafts acylations (CROSBI ID 266307)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Đud, Mateja ; Briš, Anamarija ; Jušinski, Iva ; Gracin, Davor ; Margetić, Davor
engleski
Mechanochemical Friedel–Crafts acylations
Friedel–Crafts (FC) acylation reactions were exploited in the preparation of ketone- functionalized aromatics. Environmentally more friendly, solvent-free mechanochemical reaction conditions of this industrially important reaction were developed. Reaction parameters such as FC catalyst, time, ratio of reagents and milling support were studied to establish the optimal reaction conditions. The scope of the reaction was explored by employment of different aromatic hydrocarbons in conjunction with anhydrides and acylation reagents. It was shown that certain FC-reactive aromatics could be effectively functionalized by FC acylations carried out under ball-milling conditions without the presence of a solvent. The reaction mechanism was studied by in situ Raman and ex situ IR spectroscopy.
ball milling ; Friedel–Crafts reaction ; mechanochemistry
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Podaci o izdanju
15
2019.
1313-1320
objavljeno
2195-951X
1860-5397
10.3762/bjoc.15.130