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Pregled bibliografske jedinice broj: 1007686

Protein Corona Modulates Distribution and Toxicological Effects of Silver Nanoparticles In Vivo


Barbir, Rinea; Goessler, Walter; Ćurlin, Marija; Micek, Vedran; Milić, Mirta; Vuković, Barbara; Milić, Marija; Ljubojević, Marija; Domazet Jurašin, Darija; Vinković Vrček, Ivana
Protein Corona Modulates Distribution and Toxicological Effects of Silver Nanoparticles In Vivo // Particle & particle systems characterization, 37 (2019), 1900174, 12 doi:10.1002/ppsc.201900174 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1007686 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Protein Corona Modulates Distribution and Toxicological Effects of Silver Nanoparticles In Vivo

Autori
Barbir, Rinea ; Goessler, Walter ; Ćurlin, Marija ; Micek, Vedran ; Milić, Mirta ; Vuković, Barbara ; Milić, Marija ; Ljubojević, Marija ; Domazet Jurašin, Darija ; Vinković Vrček, Ivana

Izvornik
Particle & particle systems characterization (0934-0866) 37 (2019); 1900174, 12

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
silver nanoparticles ; biodistribution ; oxidative stress ; genotoxicity ; sex differences

Sažetak
Exploitation of silver nanoparticles (AgNPs) in biomedicine represents more than one third of their overall applications. Despite their wide use, detailed toxicokinetic data and information on their action mechanisms in vivo are still scarce. One important obstacle is their fate and transformation patterns in biological environments where AgNPs get a “new face” after interaction with biomolecules, particularly proteins. The impact of protein corona on AgNP effects in vivo is eludicated. The in vivo effects of AgNPs prepared with two different protein coronas, albumin, and metallothionein, with polymer‐coated AgNPs are compared in male and female Wistar rats after intravenous administration. The results demonstrate that the character of the protein coronas on the AgNP surface affects not only distribution, but also oxidative stress response and genotoxicity in tissues of rat exposed to AgNPs. Additionally, sex‐related effects are observed. By emphasizing the importance of protein corona formation and sex‐related response, the obtained data support a reliable evidence base needed for assessing the health risks of the steadily increasing human exposure to AgNPs.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Farmacija



POVEZANOST RADA


Projekti:
HRZZ-IP-2016-06-2436 - Značaj interakcija metalnih nanočestica sa sumpornim biomolekulama za nano-bio sučelje (NanoFaceS) (Vinković Vrček, Ivana, HRZZ - 2016-06) ( POIROT)

Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb,
Klinički bolnički centar Osijek,
Medicinski fakultet, Osijek

Citiraj ovu publikaciju

Barbir, Rinea; Goessler, Walter; Ćurlin, Marija; Micek, Vedran; Milić, Mirta; Vuković, Barbara; Milić, Marija; Ljubojević, Marija; Domazet Jurašin, Darija; Vinković Vrček, Ivana
Protein Corona Modulates Distribution and Toxicological Effects of Silver Nanoparticles In Vivo // Particle & particle systems characterization, 37 (2019), 1900174, 12 doi:10.1002/ppsc.201900174 (međunarodna recenzija, članak, znanstveni)
Barbir, R., Goessler, W., Ćurlin, M., Micek, V., Milić, M., Vuković, B., Milić, M., Ljubojević, M., Domazet Jurašin, D. & Vinković Vrček, I. (2019) Protein Corona Modulates Distribution and Toxicological Effects of Silver Nanoparticles In Vivo. Particle & particle systems characterization, 37, 1900174, 12 doi:10.1002/ppsc.201900174.
@article{article, year = {2019}, pages = {12}, DOI = {10.1002/ppsc.201900174}, chapter = {1900174}, keywords = {silver nanoparticles, biodistribution, oxidative stress, genotoxicity, sex differences}, journal = {Particle and particle systems characterization}, doi = {10.1002/ppsc.201900174}, volume = {37}, issn = {0934-0866}, title = {Protein Corona Modulates Distribution and Toxicological Effects of Silver Nanoparticles In Vivo}, keyword = {silver nanoparticles, biodistribution, oxidative stress, genotoxicity, sex differences}, chapternumber = {1900174} }
@article{article, year = {2019}, pages = {12}, DOI = {10.1002/ppsc.201900174}, chapter = {1900174}, keywords = {silver nanoparticles, biodistribution, oxidative stress, genotoxicity, sex differences}, journal = {Particle and particle systems characterization}, doi = {10.1002/ppsc.201900174}, volume = {37}, issn = {0934-0866}, title = {Protein Corona Modulates Distribution and Toxicological Effects of Silver Nanoparticles In Vivo}, keyword = {silver nanoparticles, biodistribution, oxidative stress, genotoxicity, sex differences}, chapternumber = {1900174} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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