Protein Corona Modulates Distribution and Toxicological Effects of Silver Nanoparticles In Vivo (CROSBI ID 266257)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Barbir, Rinea ; Goessler, Walter ; Ćurlin, Marija ; Micek, Vedran ; Milić, Mirta ; Vuković, Barbara ; Milić, Marija ; Ljubojević, Marija ; Domazet Jurašin, Darija ; Vinković Vrček, Ivana
engleski
Protein Corona Modulates Distribution and Toxicological Effects of Silver Nanoparticles In Vivo
Exploitation of silver nanoparticles (AgNPs) in biomedicine represents more than one third of their overall applications. Despite their wide use, detailed toxicokinetic data and information on their action mechanisms in vivo are still scarce. One important obstacle is their fate and transformation patterns in biological environments where AgNPs get a “new face” after interaction with biomolecules, particularly proteins. The impact of protein corona on AgNP effects in vivo is eludicated. The in vivo effects of AgNPs prepared with two different protein coronas, albumin, and metallothionein, with polymer‐coated AgNPs are compared in male and female Wistar rats after intravenous administration. The results demonstrate that the character of the protein coronas on the AgNP surface affects not only distribution, but also oxidative stress response and genotoxicity in tissues of rat exposed to AgNPs. Additionally, sex‐related effects are observed. By emphasizing the importance of protein corona formation and sex‐related response, the obtained data support a reliable evidence base needed for assessing the health risks of the steadily increasing human exposure to AgNPs.
silver nanoparticles ; biodistribution ; oxidative stress ; genotoxicity ; sex differences
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Podaci o izdanju
37
2019.
1900174
12
objavljeno
0934-0866
1521-4117
10.1002/ppsc.201900174
Povezanost rada
Kemija, Biologija, Farmacija