Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 1007600

A novel role of bone morphogenetic protein 6 (BMP6) in glucose homeostasis


Pauk, Martina; Bordukalo-Nikšić, Tatjana; Brkljačić, Jelena; Paralkar, Vishwas; Brault, Amy; Dumić-Čule, Ivo; Borovečki, Fran; Grgurević, Lovorka; Vukičević, Slobodan
A novel role of bone morphogenetic protein 6 (BMP6) in glucose homeostasis // Acta diabetologica, 56 (2019), 3; 365-371 doi:10.1007/s00592-018-1265-1 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1007600 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
A novel role of bone morphogenetic protein 6 (BMP6) in glucose homeostasis

Autori
Pauk, Martina ; Bordukalo-Nikšić, Tatjana ; Brkljačić, Jelena ; Paralkar, Vishwas ; Brault, Amy ; Dumić-Čule, Ivo ; Borovečki, Fran ; Grgurević, Lovorka ; Vukičević, Slobodan

Izvornik
Acta diabetologica (0940-5429) 56 (2019), 3; 365-371

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Bone morphogenetic protein 6 (BMP6) ; Glucose ; Insulin ; Ob/ob mice ; PepCK

Sažetak
AIMS: Bone morphogenetic proteins (BMPs) are involved in the development and homeostasis of multiple organs and tissues. There has been a significant focus on understanding the role of BMPs in pancreatic β-cell dysfunction associated with type 2 diabetes (T2D). Our objective was to investigate the relationship between BMP6 and glucose homeostasis. METHODS: Ob/ob mice were treated with BMP6 for 6 days and analyzed for insulin release, body weight, lipid parameters and glucose tolerance. Quantitative real-time PCR, chromatin immunoprecipitation and glucose output assays were used to assess BMP6 effect on gluconeogenesis in rat hepatoma H4IIE cells. Specificity of BMP6 receptors was characterized by the utilization of various receptor Fc fusion proteins in luciferase reporter gene and glucose output assays in INS1 and H4IIE cells. RESULTS: Treatment of ob/ob mice with BMP6 for 6 days resulted in a reduction of circulating glucose and lipid levels, followed by a significantly elevated plasma insulin level in a dose-dependent manner. In addition, BMP6 improved the glucose excursion during an oral glucose tolerance test, lowering the total glycemic response by 21%. In rat H4IIE hepatoma cells, BMP6 inhibited gluconeogenesis and glucose output via downregulation the PepCK expression. Moreover, BMP6 inhibited glucose production regardless of the presence of cAMP, antagonizing its glycogenolytic effect. BMP6 acted on pancreatic and liver cells utilizing Alk3, Alk6 and ActRIIA serine/threonine kinase receptors. CONCLUSIONS: Collectively, we demonstrate that BMP6 improves glycaemia in T2D mice and regulates glucose metabolism in hepatocytes representing an exciting prospect for future treatments of diabetes.

Izvorni jezik
Engleski

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Pauk, Martina; Bordukalo-Nikšić, Tatjana; Brkljačić, Jelena; Paralkar, Vishwas; Brault, Amy; Dumić-Čule, Ivo; Borovečki, Fran; Grgurević, Lovorka; Vukičević, Slobodan
A novel role of bone morphogenetic protein 6 (BMP6) in glucose homeostasis // Acta diabetologica, 56 (2019), 3; 365-371 doi:10.1007/s00592-018-1265-1 (međunarodna recenzija, članak, znanstveni)
Pauk, M., Bordukalo-Nikšić, T., Brkljačić, J., Paralkar, V., Brault, A., Dumić-Čule, I., Borovečki, F., Grgurević, L. & Vukičević, S. (2019) A novel role of bone morphogenetic protein 6 (BMP6) in glucose homeostasis. Acta diabetologica, 56 (3), 365-371 doi:10.1007/s00592-018-1265-1.
@article{article, author = {Pauk, Martina and Bordukalo-Nik\v{s}i\'{c}, Tatjana and Brklja\v{c}i\'{c}, Jelena and Paralkar, Vishwas and Brault, Amy and Dumi\'{c}-\v{C}ule, Ivo and Borove\v{c}ki, Fran and Grgurevi\'{c}, Lovorka and Vuki\v{c}evi\'{c}, Slobodan}, year = {2019}, pages = {365-371}, DOI = {10.1007/s00592-018-1265-1}, keywords = {Bone morphogenetic protein 6 (BMP6), Glucose, Insulin, Ob/ob mice, PepCK}, journal = {Acta diabetologica}, doi = {10.1007/s00592-018-1265-1}, volume = {56}, number = {3}, issn = {0940-5429}, title = {A novel role of bone morphogenetic protein 6 (BMP6) in glucose homeostasis}, keyword = {Bone morphogenetic protein 6 (BMP6), Glucose, Insulin, Ob/ob mice, PepCK} }
@article{article, author = {Pauk, Martina and Bordukalo-Nik\v{s}i\'{c}, Tatjana and Brklja\v{c}i\'{c}, Jelena and Paralkar, Vishwas and Brault, Amy and Dumi\'{c}-\v{C}ule, Ivo and Borove\v{c}ki, Fran and Grgurevi\'{c}, Lovorka and Vuki\v{c}evi\'{c}, Slobodan}, year = {2019}, pages = {365-371}, DOI = {10.1007/s00592-018-1265-1}, keywords = {Bone morphogenetic protein 6 (BMP6), Glucose, Insulin, Ob/ob mice, PepCK}, journal = {Acta diabetologica}, doi = {10.1007/s00592-018-1265-1}, volume = {56}, number = {3}, issn = {0940-5429}, title = {A novel role of bone morphogenetic protein 6 (BMP6) in glucose homeostasis}, keyword = {Bone morphogenetic protein 6 (BMP6), Glucose, Insulin, Ob/ob mice, PepCK} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati:





    Contrast
    Increase Font
    Decrease Font
    Dyslexic Font