engleski

Cholesterol and chloride in acute heart failure

Detecting predictors of poor outcome is crucial for understanding the underlying pathophysiology of heart failure (HF) and thus creating new therapeutic concepts. It is well established that low serum lipid levels are associated with unfavorable outcomes in HF patients. Several studies examined the association between serum lipids and established predictors of mortality in HF patients. Th e aim of the present study was to examine the association of serum lipid and chloride concentrations, as well as their impact on survival in acute heart failure (AHF). Th e present study was performed as a prospective, single-centre, observational research. Th e study included 152 patients with AHF. Spearman’s correlation coeffi cient revealed a signifi cant positive correlation of serum chloride levels with serum levels of total cholesterol (ρ 0.221, p=0.006), low- density lipoprotein cholesterol (LDL-c) (ρ 0.187, p=0.015) and high-density lipoprotein- cholesterol (HDL-c) (ρ 0.169, p=0.038). Binary logistic regression revealed a signifi cant association of chloride, total cholesterol and LDL-c serum levels measured at admission with hospital survival (OR 1.077, CI 1.01-1.154, p=0.034), (OR 1.731, CI 1.090-2.748, p=0.020) and (OR 1.839, CI 1.033-3.274, p=0.038), respectively, as well as with 3-month survival (OR 1.065, CI 1.002-1.131, p=0.042), (OR 1.625, CI 1.147-2.303, p=0.006) and (OR 1.711, CI 1.117- 2.622, p=0.014), respectively. In conclusion, positive statistical association between serum cholesterol (total cholesterol, LDL-c and HDL-c) and chloride levels may suggest their similar modulation by AHF pathophysiology. Serum levels of total cholesterol, LDL-c and chloride contribute to patient survival.

heart failure ; cholesterol, LDL ; cholesterol, HDL ; lipids ; chloride

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