engleski

Primary synchronous colonic renal and lymphatic neoplasms in a patient with previous multiple baseocellular carcinomas and follicular adenoma of the thyroid

Synchronous development of primary colorectal and renal cancer is present in approximately 5% of patients with colorectal cancer. Previous non-melanoma skin cancer has been associated with worse prognosis for leukemias and colorectal cancer. We present the patient in whom synchronous colon, rectal and lymphatic malignancies (chronic lymphatic leukaemia) were incidentally diagnosed 22 years after surgery for facial baseocellular cancer and 15 years after left lobectomy for follicular adenoma of the thyroid. Patient was admitted for the treatment of pneumonia. Incidentally, severe leukocytosis was found that persisted to treatment. Bone marrow biopsy showed chronic lymphocytic leukaemia. Due to microcytic anemia, colonoscopy was performed that revealed tumor in the ascending colon involving two third of the lumen. Subsequent abdominal imaging (ultrasound and CT) demonstrated large (7.7 cm) kidney neoplasm. Right himicolectomy and left nephrectomy were performed. This represents an extremely rare combination of multiple tumors. Family DNA microassay screening may be warranted in patients with multiple neoplasms.

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