engleski

Synchronous primary carcinomas of the ampulla of Vater and ascending colon in a patient with multiple flat adenomas: a case report.

Multiple primary cancers occurring in same patients have been reported to represent 1.8% to 3.9% of all cancers. The majority of all patients reported to have had a combination of simultaneous neoplastic changes in the ampulla of Vater and the colon showed either familial adenomatous polyposis syndrome or Gardner&#8217 ; ; s syndrome. Flat adenoma syndrome is characterized clinically by many, but usually fewer than 100, colonic lesions that are characteristically slightly elevated and plaque-like, with a reddish surface and sometimes central depression. Genetically it may represent an extremely rare variant of familial adenomatous polyposis. However, there have been only a few reports that discussed concurrent neoplastic changes in the ampulla of Vater and the colon in patients with attenuated adenomatous polyposis coli. We present the clinical course and it&#8217 ; ; s clinicopathologic implications of a patient with attenuated adenomatous polyposis coli and two primary cancers: of the ampulla of Vater and ascending colon. This patient and his family history did not show polyposis compatible with familial adenomatous polyposis, Gardner&#8217 ; ; s syndrome or hereditary nonpolyposis colorectal cancer syndrome.

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