Rational approach to ophthalmic cationic nanoemulsion development (CROSBI ID 677518)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Jurišić Dukovski, Bisera ; Jurić Simčić, Ana ; Bračko, Danka ; Filipović-Grčić, Jelena ; Lovrić, Jasmina
engleski
Rational approach to ophthalmic cationic nanoemulsion development
Backgrounds: The main drawbacks of topical ocular delivery are the short residence time on ocular surface, excessive systemic absorption and limited corneal epithelial permeability. Cationic nanoemulsions for ocular delivery can provide extended residence time on ocular surface, sustained drug release and enhanced corneal permeability. Aims: The aim of this study is to develop cationic nanoemulsions with potential to improve eye-related bioavailability. Methods: Nanoemulsions were prepared by microfluidization (Model M-110EH-30 Microfluidizer, Microfluidics) using different eye-compatible oils, surfactants, cationic lipids or cationic polymers. Nanoemulsions were characterized in terms of particle size, polydispersity and zeta potential (Zetasizer 3000 HS, Malvern Instruments) and stability. The biocompatibility assessment was performed using corneal epithelial HCE-T cell line. Results: Primary screening revealed design space of formulation (combinations of oils, surfactants and cationic agents) and process parameters that resulted in nanoemulsions with targeted physico-chemical properties: droplet size 50 – 300 nm, polydispersity index 0.05 – 0.2, zeta-potential 15 – 35 mV. The formulations to be evaluated as ophthalmic drug delivery platform were selected based on stability and biocompatibility assessment. Summary/Conclusion: This screening study revealed the best nanoemulsion candidates to serve as ophthalmic delivery platform for lipophilic drugs. Further direction of the study will include the evaluation of their potential to improve eye-related bioavailability of incorporated drugs.
nanoemulsion, chitosan, stearylamine, HCE-T cells
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Podaci o prilogu
18333
2017.
objavljeno
Podaci o matičnoj publikaciji
Podaci o skupu
6th FIP Pharmaceutical Sciences World Congress
poster
21.05.2017-24.05.2017
Stockholm, Švedska